Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum

Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C ( ⁻ ), stellatumonins A and B ( and ), and stellatumonone ( ), were isolated together with ten known related compounds ( ⁻ ) from the ethyl acetate (EtOAc) extract of soft coral . The structures of the new compounds were establi...

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Bibliographic Details
Published in:Marine drugs 2018-06, Vol.16 (6), p.210
Main Authors: Ahmed, Atallah F, Chen, Yi-Wei, Huang, Chiung-Yao, Tseng, Yen-Ju, Lin, Chi-Chen, Dai, Chang-Feng, Wu, Yang-Chang, Sheu, Jyh-Horng
Format: Article
Language:English
Subjects:
Acetates
Acetic acid
Analytical methods
anti-inflammatory activity
Anti-inflammatory agents
Atolls
Cancer
Cells
cembranoid
Corals
Cyclooxygenase-2
cytotoxic activity
Cytotoxicity
Diterpenes
Ethyl acetate
Inflammation
Lipopolysaccharides
Macrophages
Metabolites
Monocytes
Nitric oxide
Nitric-oxide synthase
NMR
Nuclear magnetic resonance
Proteins
Sarcophyton
Sarcophyton stellatum
soft coral
Spectroscopy
Two dimensional analysis
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Summary:Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C ( ⁻ ), stellatumonins A and B ( and ), and stellatumonone ( ), were isolated together with ten known related compounds ( ⁻ ) from the ethyl acetate (EtOAc) extract of soft coral . The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds and were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16060210