Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-02, Vol.27 (4), p.1204
• Main Authors: Berillo, Dmitriy, Kozhahmetova, Marzhan, Lebedeva, Lina
• Format: Article
• Language: English
• Subjects: Acids; anthraquinone derivatives; Anthraquinones; Anthraquinones - chemistry; Anthraquinones - therapeutic use; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - therapeutic use; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - therapeutic use; Antiinfectives and antibacterials; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - therapeutic use; Antioxidants; Antioxidants - chemistry; Antioxidants - therapeutic use; Antitumor activity; Apoptosis; Ascites; Biological activity; Breast cancer; Cancer therapies; Cell cycle; Chemical properties; Diabetes mellitus; Drug dosages; epigallocatechin; epigallocatechin gallate; Ethanol; Flavonoids; Flavonoids - chemistry; Flavonoids - therapeutic use; Herbal medicine; High performance liquid chromatography; Hydrophobicity; Inflammation; Invasive plants; Invasiveness; Liquid chromatography; Oxidative stress; Parasitic plants; Pharmacodynamics; Pharmacokinetics; Pharmacology; Physicochemical properties; Plant extracts; Review; Rumex; Rumex - chemistry; Rumex confertus; Scientific papers; Thin layer chromatography; Viruses
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27041204

belongs to the genus and is classified as an invasive parasitic plant in agriculture. Despite other species being widely used in herbal medicine due to their antimicrobial, antioxidant, antitumor, and anti-inflammatory effects, there are almost no information about the potential of confertus for the treatment of various diseases. In this review we analyzed scientific articles revealing properties of plant's substances against cancer, diabetes, pathogenic bacterial invasions, viruses, inflammation, and oxidative stress for the past 20 years. Compounds dominating in each composition of solvents for extraction were discussed, and common thin layer chromatography(TLC) and high performance liquid chromatography(HPLC) methods for efficient separation of the plant's extract are included. Physico-chemical properties such as solubility, hydrophobicity (Log P), pKa of flavonoids, anthraquinones, and other derivatives are very important for modeling of pharmacokinetic and pharmacodynamics. An overview of clinical studies for abounded selected substances of species is presented.