IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population

Considering the immunological impairment in age-related macular degeneration (AMD), we aimed to determine the associations of IL-9 rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884 and IL-10 rs1800871, rs1800872, and rs1800896 polymorphisms and their haplotypes, as well as the serum levels...

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Bibliographic Details
Published in:Mediators of inflammation 2021, Vol.2021, p.6622934-13
Main Authors: Vilkeviciute, Alvita, Cebatoriene, Dzastina, Kriauciuniene, Loresa, Zemaitiene, Reda, Liutkeviciene, Rasa
Format: Article
Language:English
Subjects:
Age
Atrophy
Cardiovascular disease
Cataracts
Chronic illnesses
Cytokines
Diabetes
Enzyme-linked immunosorbent assay
Eye diseases
Genetic aspects
Genotyping
Haplotypes
Health sciences
Inflammation
Interleukin 10
Interleukin 9
Macular degeneration
Metabolites
Pathogenesis
Physiological aspects
Polymorphism
Serum levels
Single-nucleotide polymorphism
Type 2 diabetes
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Summary:Considering the immunological impairment in age-related macular degeneration (AMD), we aimed to determine the associations of IL-9 rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884 and IL-10 rs1800871, rs1800872, and rs1800896 polymorphisms and their haplotypes, as well as the serum levels of IL-9 and IL-10 with AMD. 1209 participants were enrolled in our study. SNPs were genotyped using TaqMan SNP genotyping assays by real-time PCR method. IL-9 and IL-10 serum levels were evaluated using ELISA kits. Our study results have shown that haplotypes A-G-C-G-G and G-A-T-A-T of IL-9 SNPs are associated with the decreased odds of early AMD occurrence (p=0.035 and p=0.015, respectively). A set of rare haplotypes was associated with the decreased odds of exudative AMD occurrence (p=0.033). Also, IL-10 serum levels were lower in exudative AMD than in controls (p=0.049), patients with early AMD (p=0.017), and atrophic AMD (p=0.008). Furthermore, exudative AMD patients with IL-10 rs1800896 CT and TT genotypes had lower IL-10 serum concentrations than those with wild-type (CC) genotype (p=0.048). In conclusion, our study suggests that IL-10 serum levels can be associated with a minor allele at IL-10 rs1800896 and exudative AMD. The haplotypes of IL-9 SNPs were also associated with the decreased odds of early and exudative AMD.
ISSN:0962-9351
1466-1861
DOI:10.1155/2021/6622934