Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

• Published in: Molecules (Basel, Switzerland) Switzerland), 2017-02, Vol.22 (2), p.268-268
• Main Authors: Abdelriheem, Nadia A, Mohamed, Ali M M, Abdelhamid, Abdou O
• Format: Article
• Language: English
• Subjects: 1,2,3-triazoles; 1,3,4-thiadiazoles; Amines; Antifungal agents; Benzaldehyde; Chloride; Data processing; Ethanol; Halides; hydrazonoyl halides; Ions; Nicotinic acid; nicotinic ester; Phenols; Pyridines; Pyridines - chemical synthesis; Sodium; Substitutes; Thiadiazoles; Thiadiazoles - chemical synthesis; Thiazoles; Thiosemicarbazones - chemistry; Triazoles; Triazoles - chemical synthesis; Urea
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22020268

In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with hydrazonoyl halides. Also, hydrazonoyl halides were reacted with thiosemicarbazone and pyrazolylthioamide to give 1,3-thiazoles derivatives. Subsequently, 3-phenyl2-en-1-one was used to synthesize substituted pyridines and substituted nicotinic acid ester. The latter was converted to its azide compound which was reacted with aromatic amines and phenol to give substituted urea and phenylcarbamate containing 1,2,3-triazole moiety. The newly synthesized compounds were established by elemental analysis, spectral data and alternative synthesis whenever possible.