Ecklonia stolonifera Extract Suppresses Lipid Accumulation by Promoting Lipolysis and Adipose Browning in High-Fat Diet-Induced Obese Male Mice

Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). Recent studies have determined that edible natural materials can reduce lipid accumulation and promote browning in WAT. We aimed to determine whether extract (ESE) woul...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-04, Vol.9 (4), p.871
Main Authors: Jin, Heegu, Lee, Kippeum, Chei, Sungwoo, Oh, Hyun-Ji, Lee, Kang-Pyo, Lee, Boo-Yong
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Adipose Tissue, Brown - drug effects
Animals
Anti-Obesity Agents - pharmacology
Anti-Obesity Agents - therapeutic use
browning
Diet, High-Fat
Ecklonia stolonifera extract
Humans
lipolysis
Lipolysis - drug effects
Male
Mice
Mice, Obese
obesity
Phaeophyceae - chemistry
Plant Extracts - chemistry
white adipose tissue
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Summary:Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). Recent studies have determined that edible natural materials can reduce lipid accumulation and promote browning in WAT. We aimed to determine whether extract (ESE) would increase the energy expenditure in high-fat diet (HFD)-induced obese mice and 3T3-L1 cells by upregulating lipolysis and browning. ESE is an edible brown marine alga that belongs to the family Laminariaceae and contains dieckol, a phlorotannin. We report that ESE inhibits body mass gain by regulating the expression of proteins involved in adipogenesis and lipogenesis. In addition, ESE activates protein kinase A (PKA) and increases the expression of lipolytic enzymes including adipose triglyceride lipase (ATGL), phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL) and also thermogenic genes, such as carnitine palmitoyltransferase 1 (CPT1), PR domain-containing 16 (PRDM16), and uncoupling protein 1 (UCP1). These findings indicate that ESE may represent a promising natural means of preventing obesity and obesity-related metabolic diseases.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9040871