Decoding Clozapine-Induced Agranulocytosis: Unraveling Interactions and Mitigation Strategies

Agranulocytosis represents a severe complication associated with the administration of clozapine. Clozapine is an antipsychotic medication that has demonstrated substantial efficacy in remediating refractory schizophrenia and various other psychiatric disorders. Nonetheless, it is crucial to monitor...

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Bibliographic Details
Published in:Pharmacy 2024-06, Vol.12 (3), p.92
Main Authors: Alalawi, Ali, Albalawi, Enas, Aljohani, Abdullah, Almutairi, Abdullah, Alrehili, Abdulraouf, Albalawi, Areej, Aldhafiri, Ahmed
Format: Article
Language:English
Subjects:
Agranulocytosis
Analysis
Antipsychotics
Apoptosis
Clinical outcomes
Clozapine
clozapine-induced agranulocytosis
Complications and side effects
Development and progression
Dosage and administration
Drug interactions
Enzymes
Granulocytopenia
Medical research
Metabolism
Metabolites
Mortality
Neutropenia
Neutrophils
Opinion
Patient safety
Prevention
Psychotropic drugs
refractory schizophrenia
Risk factors
Schizophrenia
Suicides & suicide attempts
Toxicity
White people
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Summary:Agranulocytosis represents a severe complication associated with the administration of clozapine. Clozapine is an antipsychotic medication that has demonstrated substantial efficacy in remediating refractory schizophrenia and various other psychiatric disorders. Nonetheless, it is crucial to monitor patients for neutropenia regularly during clozapine therapy. Therefore, this article aimed to delve into the prevalence of agranulocytosis during clozapine treatment by scrutinizing the extant literature to discern trends and correlations. This review endeavored to explore factors such as drug interactions, dose-related factors, duration of treatment, and genetic predispositions that could potentially influence the likelihood of patients developing agranulocytosis while undergoing clozapine therapy. Moreover, this review enunciates the ramifications of agranulocytosis on both patients and healthcare providers and meticulously evaluates the strategies to mitigate this risk and ensure optimal patient outcomes.
ISSN:2226-4787
2226-4787
DOI:10.3390/pharmacy12030092