Recent sarcopenia definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts

• Published in: Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2023-02, Vol.14 (1), p.565-575
• Main Authors: Westbury, Leo D., Beaudart, Charlotte, Bruyère, Olivier, Cauley, Jane A., Cawthon, Peggy, Cruz‐Jentoft, Alfonso J., Curtis, Elizabeth M., Ensrud, Kristine, Fielding, Roger A., Johansson, Helena, Kanis, John A., Karlsson, Magnus K., Lane, Nancy E., Lengelé, Laetitia, Lorentzon, Mattias, McCloskey, Eugene, Mellström, Dan, Newman, Anne B., Ohlsson, Claes, Orwoll, Eric, Reginster, Jean‐Yves, Ribom, Eva, Rosengren, Björn E., Schousboe, John T., Shiroma, Eric J., Harvey, Nicholas C., Dennison, Elaine M., Cooper, Cyrus
• Format: Article
• Language: English
• Subjects: Age; Aged; Ageing; Aging; Body mass index; Clinical Medicine; Cohort analysis; Cohort Studies; Consortia; determinants; Epidemiology; Ethics; Ethnicity; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; fractures; gait speed; General & Internal Medicine; Geriatrics; Geriatrics & Gerontology; Geriatrik; Human health sciences; Humans; Informed consent; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Mortality; mros; Muscle strength; Muscle Strength - physiology; older; Older people; Original; Orthopedics and Sports Medicine; Physiology (medical); Prevalence; Public Health, Global Health, Social Medicine and Epidemiology; Public health, health care sciences & services; quality-of-life; Review boards; Santé publique, services médicaux & soins de santé; Sarcopenia; Sarcopenia - complications; Sarcopenia - diagnosis; Sarcopenia - epidemiology; Sciences de la santé humaine; White people; Womens health; Working groups
• ISSN: 2190-5991; 2190-6009; 2190-6009
• DOI: 10.1002/jcsm.13160

Background The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health‐related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes. Methods White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4–6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength