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Recent sarcopenia definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts
Background The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in...
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| Published in: | Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2023-02, Vol.14 (1), p.565-575 |
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| container_title | Journal of cachexia, sarcopenia and muscle |
| container_volume | 14 |
| creator | Westbury, Leo D. Beaudart, Charlotte Bruyère, Olivier Cauley, Jane A. Cawthon, Peggy Cruz‐Jentoft, Alfonso J. Curtis, Elizabeth M. Ensrud, Kristine Fielding, Roger A. Johansson, Helena Kanis, John A. Karlsson, Magnus K. Lane, Nancy E. Lengelé, Laetitia Lorentzon, Mattias McCloskey, Eugene Mellström, Dan Newman, Anne B. Ohlsson, Claes Orwoll, Eric Reginster, Jean‐Yves Ribom, Eva Rosengren, Björn E. Schousboe, John T. Shiroma, Eric J. Harvey, Nicholas C. Dennison, Elaine M. Cooper, Cyrus |
| description | Background
The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health‐related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes.
Methods
White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4–6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength |
| doi_str_mv | 10.1002/jcsm.13160 |
| format | article |
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The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health‐related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes.
Methods
White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4–6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m2), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random‐effects meta‐analysis.
Results
Mean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow‐up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (κ = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I2: 0.0%]; SDOC [2.75 (2.28, 3.31), I2: 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I2: 58.3%].
Conclusions
There was low prevalence and poor agreement among recent sarcopenia definitions in community‐dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.]]></description><identifier>ISSN: 2190-5991</identifier><identifier>ISSN: 2190-6009</identifier><identifier>EISSN: 2190-6009</identifier><identifier>DOI: 10.1002/jcsm.13160</identifier><identifier>PMID: 36604970</identifier><language>eng</language><publisher>Germany: John Wiley & Sons, Inc</publisher><subject>Age ; Aged ; Ageing ; Aging ; Body mass index ; Clinical Medicine ; Cohort analysis ; Cohort Studies ; Consortia ; determinants ; Epidemiology ; Ethics ; Ethnicity ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; fractures ; gait speed ; General & Internal Medicine ; Geriatrics ; Geriatrics & Gerontology ; Geriatrik ; Human health sciences ; Humans ; Informed consent ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mortality ; mros ; Muscle strength ; Muscle Strength - physiology ; older ; Older people ; Original ; Orthopedics and Sports Medicine ; Physiology (medical) ; Prevalence ; Public Health, Global Health, Social Medicine and Epidemiology ; Public health, health care sciences & services ; quality-of-life ; Review boards ; Santé publique, services médicaux & soins de santé ; Sarcopenia ; Sarcopenia - complications ; Sarcopenia - diagnosis ; Sarcopenia - epidemiology ; Sciences de la santé humaine ; White people ; Womens health ; Working groups</subject><ispartof>Journal of cachexia, sarcopenia and muscle, 2023-02, Vol.14 (1), p.565-575</ispartof><rights>2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c7300-6ef2289e56ceacd00b667a0b0a8d981911e83e0bc997e1dc7c482559ae72a4a43</citedby><cites>FETCH-LOGICAL-c7300-6ef2289e56ceacd00b667a0b0a8d981911e83e0bc997e1dc7c482559ae72a4a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2771478038/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2771478038?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,11543,25734,27905,27906,36993,36994,44571,46033,46457,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36604970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512804$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/324441$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/33722327-620d-4c92-a3ec-bdbaff1a84de$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Westbury, Leo D.</creatorcontrib><creatorcontrib>Beaudart, Charlotte</creatorcontrib><creatorcontrib>Bruyère, Olivier</creatorcontrib><creatorcontrib>Cauley, Jane A.</creatorcontrib><creatorcontrib>Cawthon, Peggy</creatorcontrib><creatorcontrib>Cruz‐Jentoft, Alfonso J.</creatorcontrib><creatorcontrib>Curtis, Elizabeth M.</creatorcontrib><creatorcontrib>Ensrud, Kristine</creatorcontrib><creatorcontrib>Fielding, Roger A.</creatorcontrib><creatorcontrib>Johansson, Helena</creatorcontrib><creatorcontrib>Kanis, John A.</creatorcontrib><creatorcontrib>Karlsson, Magnus K.</creatorcontrib><creatorcontrib>Lane, Nancy E.</creatorcontrib><creatorcontrib>Lengelé, Laetitia</creatorcontrib><creatorcontrib>Lorentzon, Mattias</creatorcontrib><creatorcontrib>McCloskey, Eugene</creatorcontrib><creatorcontrib>Mellström, Dan</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Ohlsson, Claes</creatorcontrib><creatorcontrib>Orwoll, Eric</creatorcontrib><creatorcontrib>Reginster, Jean‐Yves</creatorcontrib><creatorcontrib>Ribom, Eva</creatorcontrib><creatorcontrib>Rosengren, Björn E.</creatorcontrib><creatorcontrib>Schousboe, John T.</creatorcontrib><creatorcontrib>Shiroma, Eric J.</creatorcontrib><creatorcontrib>Harvey, Nicholas C.</creatorcontrib><creatorcontrib>Dennison, Elaine M.</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>International Musculoskeletal Ageing Network</creatorcontrib><creatorcontrib>the International Musculoskeletal Ageing Network</creatorcontrib><title>Recent sarcopenia definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts</title><title>Journal of cachexia, sarcopenia and muscle</title><addtitle>J Cachexia Sarcopenia Muscle</addtitle><description><![CDATA[Background
The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health‐related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes.
Methods
White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4–6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m2), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random‐effects meta‐analysis.
Results
Mean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow‐up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (κ = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I2: 0.0%]; SDOC [2.75 (2.28, 3.31), I2: 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I2: 58.3%].
Conclusions
There was low prevalence and poor agreement among recent sarcopenia definitions in community‐dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.]]></description><subject>Age</subject><subject>Aged</subject><subject>Ageing</subject><subject>Aging</subject><subject>Body mass index</subject><subject>Clinical Medicine</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Consortia</subject><subject>determinants</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Ethnicity</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>fractures</subject><subject>gait speed</subject><subject>General & Internal Medicine</subject><subject>Geriatrics</subject><subject>Geriatrics & Gerontology</subject><subject>Geriatrik</subject><subject>Human health sciences</subject><subject>Humans</subject><subject>Informed consent</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Mortality</subject><subject>mros</subject><subject>Muscle strength</subject><subject>Muscle Strength - physiology</subject><subject>older</subject><subject>Older people</subject><subject>Original</subject><subject>Orthopedics and Sports Medicine</subject><subject>Physiology (medical)</subject><subject>Prevalence</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Public health, health care sciences & services</subject><subject>quality-of-life</subject><subject>Review boards</subject><subject>Santé publique, services médicaux & soins de santé</subject><subject>Sarcopenia</subject><subject>Sarcopenia - complications</subject><subject>Sarcopenia - diagnosis</subject><subject>Sarcopenia - epidemiology</subject><subject>Sciences de la santé humaine</subject><subject>White people</subject><subject>Womens health</subject><subject>Working 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definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts</title><author>Westbury, Leo D. ; Beaudart, Charlotte ; Bruyère, Olivier ; Cauley, Jane A. ; Cawthon, Peggy ; Cruz‐Jentoft, Alfonso J. ; Curtis, Elizabeth M. ; Ensrud, Kristine ; Fielding, Roger A. ; Johansson, Helena ; Kanis, John A. ; Karlsson, Magnus K. ; Lane, Nancy E. ; Lengelé, Laetitia ; Lorentzon, Mattias ; McCloskey, Eugene ; Mellström, Dan ; Newman, Anne B. ; Ohlsson, Claes ; Orwoll, Eric ; Reginster, Jean‐Yves ; Ribom, Eva ; Rosengren, Björn E. ; Schousboe, John T. ; Shiroma, Eric J. ; Harvey, Nicholas C. ; Dennison, Elaine M. ; Cooper, Cyrus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7300-6ef2289e56ceacd00b667a0b0a8d981911e83e0bc997e1dc7c482559ae72a4a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Aged</topic><topic>Ageing</topic><topic>Aging</topic><topic>Body mass index</topic><topic>Clinical Medicine</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Consortia</topic><topic>determinants</topic><topic>Epidemiology</topic><topic>Ethics</topic><topic>Ethnicity</topic><topic>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</topic><topic>fractures</topic><topic>gait speed</topic><topic>General & Internal Medicine</topic><topic>Geriatrics</topic><topic>Geriatrics & Gerontology</topic><topic>Geriatrik</topic><topic>Human health sciences</topic><topic>Humans</topic><topic>Informed consent</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Mortality</topic><topic>mros</topic><topic>Muscle strength</topic><topic>Muscle Strength - physiology</topic><topic>older</topic><topic>Older people</topic><topic>Original</topic><topic>Orthopedics and Sports Medicine</topic><topic>Physiology (medical)</topic><topic>Prevalence</topic><topic>Public Health, Global Health, Social Medicine and Epidemiology</topic><topic>Public health, health care sciences & services</topic><topic>quality-of-life</topic><topic>Review boards</topic><topic>Santé publique, services médicaux & soins de santé</topic><topic>Sarcopenia</topic><topic>Sarcopenia - complications</topic><topic>Sarcopenia - diagnosis</topic><topic>Sarcopenia - epidemiology</topic><topic>Sciences de la santé humaine</topic><topic>White people</topic><topic>Womens health</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westbury, Leo D.</creatorcontrib><creatorcontrib>Beaudart, Charlotte</creatorcontrib><creatorcontrib>Bruyère, Olivier</creatorcontrib><creatorcontrib>Cauley, Jane A.</creatorcontrib><creatorcontrib>Cawthon, Peggy</creatorcontrib><creatorcontrib>Cruz‐Jentoft, Alfonso J.</creatorcontrib><creatorcontrib>Curtis, Elizabeth M.</creatorcontrib><creatorcontrib>Ensrud, Kristine</creatorcontrib><creatorcontrib>Fielding, Roger A.</creatorcontrib><creatorcontrib>Johansson, Helena</creatorcontrib><creatorcontrib>Kanis, John A.</creatorcontrib><creatorcontrib>Karlsson, Magnus K.</creatorcontrib><creatorcontrib>Lane, Nancy E.</creatorcontrib><creatorcontrib>Lengelé, Laetitia</creatorcontrib><creatorcontrib>Lorentzon, Mattias</creatorcontrib><creatorcontrib>McCloskey, Eugene</creatorcontrib><creatorcontrib>Mellström, Dan</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Ohlsson, Claes</creatorcontrib><creatorcontrib>Orwoll, Eric</creatorcontrib><creatorcontrib>Reginster, Jean‐Yves</creatorcontrib><creatorcontrib>Ribom, Eva</creatorcontrib><creatorcontrib>Rosengren, Björn E.</creatorcontrib><creatorcontrib>Schousboe, John T.</creatorcontrib><creatorcontrib>Shiroma, Eric J.</creatorcontrib><creatorcontrib>Harvey, Nicholas C.</creatorcontrib><creatorcontrib>Dennison, Elaine M.</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>International Musculoskeletal Ageing Network</creatorcontrib><creatorcontrib>the International Musculoskeletal Ageing Network</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Free Archive</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Lunds universitet</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westbury, Leo D.</au><au>Beaudart, Charlotte</au><au>Bruyère, Olivier</au><au>Cauley, Jane A.</au><au>Cawthon, Peggy</au><au>Cruz‐Jentoft, Alfonso J.</au><au>Curtis, Elizabeth M.</au><au>Ensrud, Kristine</au><au>Fielding, Roger A.</au><au>Johansson, Helena</au><au>Kanis, John A.</au><au>Karlsson, Magnus K.</au><au>Lane, Nancy E.</au><au>Lengelé, Laetitia</au><au>Lorentzon, Mattias</au><au>McCloskey, Eugene</au><au>Mellström, Dan</au><au>Newman, Anne B.</au><au>Ohlsson, Claes</au><au>Orwoll, Eric</au><au>Reginster, Jean‐Yves</au><au>Ribom, Eva</au><au>Rosengren, Björn E.</au><au>Schousboe, John T.</au><au>Shiroma, Eric J.</au><au>Harvey, Nicholas C.</au><au>Dennison, Elaine M.</au><au>Cooper, Cyrus</au><aucorp>International Musculoskeletal Ageing Network</aucorp><aucorp>the International Musculoskeletal Ageing Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent sarcopenia definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts</atitle><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle><addtitle>J Cachexia Sarcopenia Muscle</addtitle><date>2023-02</date><risdate>2023</risdate><volume>14</volume><issue>1</issue><spage>565</spage><epage>575</epage><pages>565-575</pages><issn>2190-5991</issn><issn>2190-6009</issn><eissn>2190-6009</eissn><abstract><![CDATA[Background
The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health‐related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes.
Methods
White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4–6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m2), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random‐effects meta‐analysis.
Results
Mean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow‐up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (κ = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I2: 0.0%]; SDOC [2.75 (2.28, 3.31), I2: 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I2: 58.3%].
Conclusions
There was low prevalence and poor agreement among recent sarcopenia definitions in community‐dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.]]></abstract><cop>Germany</cop><pub>John Wiley & Sons, Inc</pub><pmid>36604970</pmid><doi>10.1002/jcsm.13160</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2190-5991 |
| ispartof | Journal of cachexia, sarcopenia and muscle, 2023-02, Vol.14 (1), p.565-575 |
| issn | 2190-5991 2190-6009 2190-6009 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_6cf7d4d2fefb4b71800895ecc46edd4a |
| source | Wiley-Blackwell Open Access Collection; Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Age Aged Ageing Aging Body mass index Clinical Medicine Cohort analysis Cohort Studies Consortia determinants Epidemiology Ethics Ethnicity Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi fractures gait speed General & Internal Medicine Geriatrics Geriatrics & Gerontology Geriatrik Human health sciences Humans Informed consent Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Mortality mros Muscle strength Muscle Strength - physiology older Older people Original Orthopedics and Sports Medicine Physiology (medical) Prevalence Public Health, Global Health, Social Medicine and Epidemiology Public health, health care sciences & services quality-of-life Review boards Santé publique, services médicaux & soins de santé Sarcopenia Sarcopenia - complications Sarcopenia - diagnosis Sarcopenia - epidemiology Sciences de la santé humaine White people Womens health Working groups |
| title | Recent sarcopenia definitions—prevalence, agreement and mortality associations among men: Findings from population‐based cohorts |
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