Highlights in Resistance Mechanism Pathways for Combination Therapy

Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-08, Vol.8 (9), p.1013
Main Authors: Delou, João M A, Souza, Alana S O, Souza, Leonel C M, Borges, Helena L
Format: Article
Language:English
Subjects:
ABC transporters
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Antitumor agents
Cancer therapies
Cell cycle
Cell death
Chemoresistance
Chemotherapy
Clinical trials
cytotoxic chemotherapy
Cytotoxicity
Drug resistance
Drug Resistance, Neoplasm
drugs mechanisms of action
Enzymes
FDA approval
hallmarks of cancer
Homeostasis
Humans
Leukemia
Metabolism
Mutation
Neoplasms - drug therapy
Pharmaceutical industry
resistance mechanisms
Review
Signal transduction
Signal Transduction - drug effects
targeted therapy
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Summary:Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective induction of cancer cell death. We consider this review an extensive compilation of updated known information on chemotherapy resistance mechanisms to promote new combination therapies to be to discussed and tested.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8091013