Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans

Glycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as O-, N-, and carboxyl-modified, which significantly increase the...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-10, Vol.28 (20), p.7112
Main Authors: Tian, Guangzong, Qin, Chunjun, Hu, Jing, Zou, Xiaopeng, Yin, Jian
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Bacterial infections
bacterial surface glycans
biological activities
Biological activity
carbohydrate antigens
Carbohydrates
E coli
functional groups
Identification
Immune system
immunogenicity
Immunology
Infectious diseases
Medical research
NMR
Nuclear magnetic resonance
Polysaccharides
Review
Streptococcus infections
Sugar
Tetanus antitoxin
Vaccines
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Summary:Glycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as O-, N-, and carboxyl-modified, which significantly increase the diversity of glycan structures. These functional groups are not only crucial for glycans’ structural identity but are also essential for their biological functions. Therefore, a clear understanding of the biological functions of these modified groups in corresponding bacterial glycans is crucial for their medical applications. Thus far, the activities of functional groups in some biomedical active carbohydrates have been elucidated. It has been shown that some functional groups are key constituents of biologically active bacterial glycans, while others are actually not essential and may even mask the functions of the glycans. This paper reviews the structures of naturally occurring side-chain functional groups in glycans located on the bacterial surface and their roles in immunological responses.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28207112