Microneedle patch casting using a micromachined carbon master for enhanced drug delivery

For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loa...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.19228-10
Main Authors: Choi, Hye Jin, Ullah, Asad, Jang, Mi Jin, Lee, Ui Seok, Shin, Min Chul, An, Sang Hyun, Kim, Dongseon, Kim, Bo Hyun, Kim, Gyu Man
Format: Article
Language:English
Subjects:
639/166
639/301
692/700
Animals
Carbon
Carbon - chemistry
Channel pores
Drug delivery
Drug Delivery Systems - methods
Drug Liberation
Humanities and Social Sciences
Hydrogen-Ion Concentration
Medical treatment
Mice
Microinjections - instrumentation
Microinjections - methods
Micromechanical machining
Microneedles
multidisciplinary
Needles
pH effects
Polymers
Polymers - chemistry
Porosity
Porous polymer coating
Sampling
Science
Science (multidisciplinary)
Stimulus release
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Summary:For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Microcavities were formed on a carbon plate via micromechanical machining. A porous polymer layer was coated on a microneedle patch (MNP). The pores of the porous polymer layer provided space and channels for drug delivery. A pH-sensitive polymer layer was employed to cap the porous polymer layer, which prevented drug leakage during storage and provided a stimulus drug release in response to body pH conditions. The drug can be delivered through holes connected to both sides of the patch. The drug release of the MNP was investigated in vitro and in vivo and showed conceptual proof that these MNs have the potential to enhance treatment protocols for various diseases with the flexibility of coating and therapeutic materials and offer significant scope for further variations and advancement.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-70393-8