Generation of induced pluripotent stem cells (cmESF-iPS-C5) derived from cynomolgus monkey ear skin fibroblasts (cmESF)

Cynomolgus monkeys, due to their close anatomical, genetic and physiological similarity to humans, have been employed as a popular laboratory non-human primate model over rodents. Primate animal induced pluripotent stem cell (iPSC) have been used to aid on the investigation of autologous regenerativ...

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Bibliographic Details
Published in:Stem cell research 2022-12, Vol.65, p.102977-102977, Article 102977
Main Authors: Zhen, Xing, Park, Sang-Je, Choe, Se-Hee, Lee, Dong-Seok, Lee, Jong-Hee
Format: Article
Language:English
Subjects:
Animals
Induced Pluripotent Stem Cells
Macaca fascicularis
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Summary:Cynomolgus monkeys, due to their close anatomical, genetic and physiological similarity to humans, have been employed as a popular laboratory non-human primate model over rodents. Primate animal induced pluripotent stem cell (iPSC) have been used to aid on the investigation of autologous regenerative therapies. Here, we reprogrammed cynomolgus monkey ear skin fibroblasts (cmESFs) into iPSCs as a starting material for autologous based study. The resulting cmESF-iPSCs with canonical features of PSCs will advance the development of autologous transplantation.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102977