Nevus Comedonicus Syndrome Associated with Psychiatric Disorder

Nevus comedonicus (NC) is a rare hamartoma of the pilosebaceous unit origin. The association with extracutaneous abnormalities defines NC syndrome (NCS). Fewer than 50 cases of NCS have been reported in the English literature. A 31-year-old woman presented with grouped and linear comedonal papules p...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-02, Vol.12 (2), p.383
Main Authors: Woo, Ha Young, Kim, Sang Kyum
Format: Article
Language:English
Subjects:
attention-deficit hyperactivity disorder
Cardiac arrhythmia
Case Report
Cell cycle
Conflicts of interest
Congenital diseases
Emotional disorders
epidermal nevus syndrome
Hyperplasia
Keratin
Mental disorders
Mood disorders
Mutation
Nervous system
nevus comedonicus
nevus comedonicus syndrome
Patients
Scoliosis
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Summary:Nevus comedonicus (NC) is a rare hamartoma of the pilosebaceous unit origin. The association with extracutaneous abnormalities defines NC syndrome (NCS). Fewer than 50 cases of NCS have been reported in the English literature. A 31-year-old woman presented with grouped and linear comedonal papules present from birth and located on the left buttock along Blaschko's lines. She had a history of pediatric mood disorder combined with attention-deficit hyperactivity disorder (ADHD) from 5 years of age and was recently diagnosed with sinus bradycardia. Her skin lesion was surgically removed and microscopic findings revealed the aggregation of dilated follicular infundibula filled with prominent laminated keratin plugs, a characteristic finding of NC. This is the first report presenting NCS associated with mood disorder and ADHD. Psychiatric symptoms may represent systemic manifestation of NCS.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12020383