Sputum pathogen spectrum and clinical outcomes of upper respiratory tract infection in bronchiectasis exacerbation: a prospective cohort study

Upper respiratory tract infection (URTI) is common in humans. We sought to profile sputum pathogen spectrum and impact of URTI on acute exacerbation of bronchiectasis (AE). Between March 2017 and December 2021, we prospectively collected sputum from adults with bronchiectasis. We stratified AEs into...

Full description

Saved in:
Bibliographic Details
Published in:Emerging microbes & infections 2023-12, Vol.12 (1), p.2202277
Main Authors: Huang, Yan, Chen, Chun-lan, Cen, Lai-jian, Li, Hui-min, Lin, Zhen-hong, Zhu, Si-yu, Duan, Chong-yang, Zhang, Ri-lan, Pan, Cui-xia, Zhang, Xiao-fen, Zhang, Xiao-xian, He, Zhen-feng, Shi, Ming-xin, Zhong, Nan-shan, Guan, Wei-jie
Format: Article
Language:English
Subjects:
Adult
bronchiectasis
Bronchiectasis - complications
Bronchiectasis - microbiology
Clinical outcomes
Cohort analysis
exacerbation
Humans
Pathogens
Prospective Studies
Respiratory Tract Infections
Rhinovirus - genetics
Sputum - microbiology
symptom burden
Upper respiratory tract infections
virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Upper respiratory tract infection (URTI) is common in humans. We sought to profile sputum pathogen spectrum and impact of URTI on acute exacerbation of bronchiectasis (AE). Between March 2017 and December 2021, we prospectively collected sputum from adults with bronchiectasis. We stratified AEs into events related (URTI-AE) and unrelated to URTI (non-URTI-AE). We captured URTI without onset of AE (URTI-non-AE). We did bacterial culture and viral detection with polymerase chain reaction, and explored the pathogen spectrum and clinical impacts of URTI-AE via longitudinal follow-up. Finally, we collected 479 non-AE samples (113 collected at URTI-non-AE and 225 collected at clinically stable) and 170 AE samples (89 collected at URTI-AE and 81 collect at non-URTI-AE). The viral detection rate was significantly higher in URTI-AE (46.1%) than in non-URTI-AE (4.9%) and URTI-non-AE (11.5%) (both P 
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2023.2202277