Occupational exposure and new-onset asthma in the population-based Telemark study: a 5-year follow-up

• Published in: BMJ open 2024-09, Vol.14 (9), p.e090131
• Main Authors: Zivadinovic, Nikola, Jaoiun, Keson, Klepaker, Geir, Wagstaff, Anthony, Torén, Kjell, Henneberger, Paul K, Kongerud, Johny, Abrahamsen, Regine, Fell, Anne Kristin Moeller
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Allmän medicin; Antigens; Asthma; Asthma - epidemiology; Asthma - etiology; Body mass index; Cross-sectional studies; Dust; epidemiology; Family Medicine; Female; Follow-Up Studies; Humans; Incidence; Logistic Models; Longitudinal Studies; Lung diseases; Male; Middle Aged; Missing data; Norway - epidemiology; occupational & industrial medicine; Occupational and Environmental Medicine; Occupational Diseases - epidemiology; Occupational Diseases - etiology; Occupational Exposure - adverse effects; Occupational Exposure - statistics & numerical data; Original Research; Questionnaires; Regression analysis; Risk Factors; Self Report; Smoking; Young Adult
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2024-090131

ObjectivesThis study aimed to estimate the incidence of asthma and assess the association between job exposure matrix (N-JEM) assigned occupational exposure, self-reported occupational exposure to vapour, gas, dust and fumes (VGDF), mould, damages from moisture and cold, and new-onset asthma. We also aimed to assess the corresponding population attributable fraction (PAF) for ever exposure to VGDF.DesignLongitudinal population-based respiratory health study.SettingResponders from the baseline Telemark Study in south-eastern Norway were followed up from 2013 to 2018.Participants7120 participants, aged 16–55, were followed during a 5-year period.Main outcome measuresNew-onset asthma and its association with self-reported occupational exposure to VGDF, data from the N-JEM and self-reported workplace conditions were assessed using logistic regression adjusted for gender, age, smoking and body mass index. The PAF was calculated using the PUNAF command in STATA.ResultsThere were 266 (3.7%) cases of new-onset asthma and an incidence density of 7.5 cases per 1000 person-years. A statistically significant association was found for ever exposed to VGDF with an OR of 1.49 (95% CI 1.15 to 1.94), weekly OR 2.00 (95% CI 1.29 to 3.11) and daily OR 2.46 (95% CI 1.39 to 4.35) exposure to VGDF. The corresponding PAF for ever exposed to VGDF was 17% (95% CI 5.4% to 27.8%) and the risk of asthma onset increased with frequent VGDF exposure, indicating a possible exposure–response relationship (p=0.002 for trend). The N-JEM exposure group, accidental peak exposure to irritants had an increased risk of new-onset asthma, OR 2.43 (95% CI 1.21 to 4.90). A significant association was also found for self-reported exposure to visible damages due to moisture 1.51 (95% CI 1.08 to 2.11), visible and smell of mould 1.88 (95% CI 1.32 to 2.68), 1.55 (95% CI 1.12 to 2.16) and cold environment 1.41 (95% CI 1.07 to 1.86).ConclusionParticipants had elevated ORs for asthma associated with self-reported and N-JEM-assigned exposures. A PAF of 17% indicates that work-related asthma is still common. The possible exposure–response relationship suggests that reducing occupational VGDF exposure frequency could prevent the onset of asthma.