Photoacoustic Imaging of pH-Sensitive Optical Sensors in Biological Tissues

Photoacoustic imaging is an emerging biomedical imaging technique that enables non-invasive visualization of the optical absorption properties of biological tissues in vivo. Although numerous studies have used contrast agents to achieve high-contrast imaging in deep tissues, targeting specific areas...

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Bibliographic Details
Published in:Chemosensors 2024-12, Vol.12 (12), p.257
Main Authors: Kye, Hyunjun, Jo, Dongyoung, Jeong, Sanghwa, Kim, Chulhong, Kim, Jeesu
Format: Article
Language:English
Subjects:
Acoustics
Biological properties
Biomedical engineering
Biomedical materials
Comparative analysis
Contrast agents
Contrast media
Drug delivery
Drug delivery systems
Drugs
Efficiency
Hydrogen-ion concentration
Imaging techniques
In vivo methods and tests
Lasers
Light
Medical electronics
Medical imaging
Microscopy
nanomaterials
Optical measuring instruments
Optical properties
pH effects
pH-sensitive sensor
photoacoustic imaging
Sensors
Tissues
Tomography
tumor detection
Tumor microenvironment
Tumors
Ultrasonic imaging
Vehicles
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Summary:Photoacoustic imaging is an emerging biomedical imaging technique that enables non-invasive visualization of the optical absorption properties of biological tissues in vivo. Although numerous studies have used contrast agents to achieve high-contrast imaging in deep tissues, targeting specific areas remains a challenge when using agents that are continuously activated. Recent research has focused on developing triggered contrast agents that are selectively activated in target areas. This review delves into the use of pH-triggered contrast agents in photoacoustic imaging, which take advantage of the lower pH of the tumor microenvironment compared to normal tissues. The paper discusses the mechanisms of pH-triggered contrast agents that contribute to improving depth and contrast in photoacoustic tumor imaging. In addition, the integration of functionalities, such as photothermal therapy and drug delivery monitoring, into these agents demonstrates significant potential for biomedical applications.
ISSN:2227-9040
2227-9040
DOI:10.3390/chemosensors12120257