Hepatoblastoma with precocious puberty

Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious p...

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Bibliographic Details
Published in:Journal of Indian Association of Pediatric Surgeons 2019-01, Vol.24 (1), p.68-71
Main Authors: Yhoshu, Enono, Lone, Yasir, Mahajan, Jai, Singh, Umesh
Format: Article
Language:English
Subjects:
Abdomen
Age
Case Report
Chemotherapy
Hepatoblastoma
Hormones
Liver
Liver cancer
precocious
Puberty
Surgery
Testosterone
virilization
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Summary:Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.
ISSN:0971-9261
1998-3891
DOI:10.4103/jiaps.JIAPS_102_18