RETRACTED ARTICLE: Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial

• Published in: Journal of orthopaedic surgery and research 2021-05, Vol.16 (1), p.1-14, Article 290
• Main Authors: Alves, J. C., dos Santos, Ana Margarida Moniz Pereira, Jorge, Patrícia, Lavrador, Catarina Falcão Trigoso Vieira Bran, Carreira, L. Miguel
• Format: Article
• Language: English
• Subjects: Animal model; Clinical metrology instruments; Dog; High molecular weight hyaluronan; Osteoarthritis; Pain
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-021-02423-4

Abstract Background Osteoarthritis (OA) is a complex joint disease and chronic pain source, affecting a patient’s quality of life and posing a financial burden. As the dog is considered a nearly ideal species for translation research of human OA and the most used model for research, exploring spontaneous dog OA under the One Health/One Medicine concept can improve both humans and dogs’ health and well-being. Methods In a clinical treatment experiment, forty (N=40) joints were selected and randomly assigned to a control group (CG), which received 0.9% NaCl or a treatment (HG), which received Hylan G-F 20. Evaluations were performed on treatment day (T0), 8, 15, 30, 90, and 180 days post-treatment. They consisted of four different Clinical Metrology Instruments (CMI), evaluation of weight distribution, joint range of motion, thigh girth, radiographic and digital thermography imaging, synovial fluid interleukin-1 (IL-1), and C-reactive protein concentrations. Results were compared with repeated measures ANOVA, with a Huynh-Feldt correction, Paired samples T-test, or Wilcoxon signed-ranks test, with p