Research progress in toxicological effects and mechanism of aflatoxin B1 toxin

Fungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2022-08, Vol.10, p.e13850
Main Authors: Li, Congcong, Liu, Xiangdong, Wu, Jiao, Ji, Xiangbo, Xu, Qiuliang
Format: Article
Language:English
Subjects:
Aflatoxin B1
Agricultural Science
Apoptosis
Autophagy
Biochemistry
Carcinogens
Cattle
Cell cycle
Cell proliferation
Climate change
Endoplasmic reticulum
Enzymes
Feeds
Food contamination
Food contamination & poisoning
Liver
Livestock
Mechanisms
Metabolites
Molecular modelling
Mutation
Mycology
Mycotoxins
Neurotoxicity
Oxidative stress
Poultry
Regulation
Risk factors
Secondary metabolites
Toxicities
Toxicity
Toxicology
Urine
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Summary:Fungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor for both humans and animals. AFTs are ubiquitous in the environment, soil, and food crops, and aflatoxin B1(AFB1) has been identified by the World Health Organization (WHO) as one of the most potent natural group 1A carcinogen. We reviewed the literature on the toxic effects of AFB1 in humans and animals along with its toxicokinetic properties. The damage induced by AFB1 in cells and tissues is mainly achieved through cell cycle arrest and inhibition of cell proliferation, and the induction of apoptosis, oxidative stress, endoplasmic reticulum (ER) stress and autophagy. In addition, numerous coding genes and non-coding RNAs have been identified that regulate AFB1 toxicity. This review is a summary of the current research on the complexity of AFB1 toxicity, and provides insights into the molecular mechanisms as well as the phenotypic characteristics.
ISSN:2167-8359
DOI:10.7717/peerj.13850