Short-term serial assessment of electronic patient-reported outcome for depression and anxiety in breast Cancer

• Published in: BMC cancer 2021-09, Vol.21 (1), p.1-1065, Article 1065
• Main Authors: Lee, Jeeyeon, Jung, Jin Hyang, Kim, Wan Wook, Kang, Byeongju, Woo, Jungmin, Rim, Hyo-Deog, Chae, Yee Soo, Lee, Soo Jung, Kim, Gi Hwan, Lee, Won Kee, Park, Ho Yong
• Format: Article
• Language: English
• Subjects: Anxiety; Anxiety disorders; Body mass index; Breast cancer; Cancer; Cancer therapies; Care and treatment; Chemotherapy; Complications and side effects; Depression; Depression, Mental; Electronic records; Hormone replacement therapy; Management; Mental depression; Mental disorders; Mental health; Oncology, Experimental; Patients; Physicians; Questionnaires; Risk factors; Serial assessment; Sleep disorders; Smartphones; Statistical analysis; Surgery
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-021-08771-y

Purpose The incidence of depression and anxiety is higher in patients with breast cancer than in the general population. We evaluated the degree of depression and anxiety and investigated the changes in patients with breast cancer during the treatment period and short-term follow-up period. Methods Overall, 137 patients with breast cancer were evaluated using the Patient Health Questionnaire 9-item depression scale (PHQ-9) and Generalized Anxiety Disorder scale (GAD-7). The scales were developed as a web-based electronic patient-reported outcome measure, and serial results were assessed before the operation, after the operation, in the post-treatment period, and in the 6-month follow-up period after surgery. Results The degree of depression and anxiety increased during treatment and decreased at 6-month follow-up, even if there were no statistical differences among the four periods (PHQ-9: p = 0.128; GAD-7: p = 0.786). However, daily fatigue (PHQ-9 Q4) and insomnia (PHQ-9 Q3) were the most serious problems encountered during treatment and at 6-month follow-up, respectively. In the GAD-7, worrying too much (Q3) consistently showed the highest scores during the treatment and follow-up periods. Of the patients, 7 (5.11%) and 11 (8.03%) patients had a worsened state of depression and anxiety, respectively, after treatment compared with before treatment. Conclusion Most factors associated with depression and anxiety improved after treatment. However, factors such as insomnia and worrying too much still disturbed patients with breast cancer, even at 6-month follow-up. Therefore, serial assessment of depression and anxiety is necessary for such patients. Keywords: Breast cancer, Depression, Anxiety, Serial assessment