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Assessing the kidney function parameters glomerular filtration rate and effective renal plasma flow with dynamic FDG-PET/MRI in healthy subjects
Background A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[ 18 F]fluoro- d -glucose (FDG) concentration behavior in kidneys, measured with positron emission tomography (PET) scans. Twenty-four healthy adul...
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Published in: | EJNMMI research 2018-05, Vol.8 (1), p.37-9, Article 37 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[
18
F]fluoro-
d
-glucose (FDG) concentration behavior in kidneys, measured with positron emission tomography (PET) scans.
Twenty-four healthy adult subjects prospectively underwent dynamic simultaneous PET/magnetic resonance imaging (MRI) examination. Time activity curves (TACs) were obtained from the dynamic PET series, with the guidance of MR information. Patlak analysis was performed to determine the GFR, and based on integrals, ERPF was calculated. Results were compared to intra-individually obtained reference values determined from venous blood samples.
Results
Total kidney GFR and ERPF as estimated by dynamic PET/MRI were highly correlated to their reference values (
r
= 0.88/
p
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ISSN: | 2191-219X 2191-219X |
DOI: | 10.1186/s13550-018-0389-1 |