Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome

This case details a rapid diagnosis of legionella pneumonia causing severe acute respiratory distress syndrome (ARDS) in an otherwise healthy adolescent through plasma microbial cell-free DNA next generation sequencing (mcfDNA-NGS). Diagnosis by mcfDNA-NGS of this unexpected pathogen led to narrowin...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pediatrics 2022-12, Vol.10, p.1034632
Main Authors: Rodriguez, Katherine M, Ramchandar, Nanda, Coufal, Nicole G
Format: Article
Language:English
Subjects:
acute respiratory distress syndrome
legionella
pediatric critical care
Pediatrics
plasma microbial cell-free DNA next generation sequencing
pneumonia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This case details a rapid diagnosis of legionella pneumonia causing severe acute respiratory distress syndrome (ARDS) in an otherwise healthy adolescent through plasma microbial cell-free DNA next generation sequencing (mcfDNA-NGS). Diagnosis by mcfDNA-NGS of this unexpected pathogen led to narrowing of antimicrobials and the addition of glucocorticoids as adjunctive therapy for ARDS.
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2022.1034632