Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study

This study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population. 172 adults were enrolled from the Qingdao Municipal Hospital from May 2019 to October 2020. All individuals were examined with MRI-PDFF and divided into no steatosis,...

Full description

Saved in:
Bibliographic Details
Published in:BMC gastroenterology 2022-01, Vol.22 (1), p.6-6, Article 6
Main Authors: Ma, Xuefeng, Zheng, Xu, Liu, Shousheng, Zhuang, Likun, Wang, Mengke, Wang, Yifen, Xin, Yongning, Xuan, Shiying
Format: Article
Language:English
Subjects:
Adult
Age
Apolipoproteins
Bilirubin
Bilirubin - blood
Biopsy
Body mass index
Cross-Sectional Studies
Development and progression
Fatty liver
Gastroenterology
Glucuronosyltransferase - blood
Glycosyltransferases
Health aspects
Hemoglobin
Hepatitis
High density lipoprotein
History of medicine
Humans
Insulin
Liver
Liver diseases
Magnetic Resonance Imaging
Magnetic resonance imaging proton density fat fraction
Measurement
Non-alcoholic Fatty Liver Disease - diagnosis
Nonalcoholic fatty liver disease
Patients
Risk factors
Statistical analysis
Steatosis
UDP-glucuronosyltransferase 1A1
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population. 172 adults were enrolled from the Qingdao Municipal Hospital from May 2019 to October 2020. All individuals were examined with MRI-PDFF and divided into no steatosis, mild steatosis, moderate steatosis, and severe steatosis groups according to the MRI-PDFF values. The biochemical indexes and UGT1A1 were measured. There was no significant difference of circulating TB and UGT1A1 levels between NAFLD group and controls. In the moderate steatosis and severe steatosis groups, the circulating TB levels were higher than that in control group (all P 
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-021-02088-7