Genetic variants linked to T2DM risk in Kurdish populations

The polymorphisms of the C-C chemokine receptor type 5 ( ) and the insulin receptor substrate 1 ( 1) have been studied as candidates for the susceptibility to develop type 2 diabetes mellitus (T2DM). is a chemokine receptor, and the polymorphisms in the promoter region of this receptor are being stu...

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Bibliographic Details
Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2019-04, Vol.12, p.431-437
Main Authors: Golsheh, Shadi, Keshavarzi, Fatemeh
Format: Article
Language:English
Subjects:
Alleles
Anopheles
CCR5 (59029A/G)
Chemokines
Development and progression
Diabetes
Diabetes mellitus
DNA
Genes
Genetic aspects
Genetic polymorphisms
Genotypes
Health risk assessment
Insulin
IRS1 (rs10498210)
Kurdish patients
Kurdish people
Kurds
Mutation
Original Research
Polymorphism
Population
Type 2 diabetes
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Summary:The polymorphisms of the C-C chemokine receptor type 5 ( ) and the insulin receptor substrate 1 ( 1) have been studied as candidates for the susceptibility to develop type 2 diabetes mellitus (T2DM). is a chemokine receptor, and the polymorphisms in the promoter region of this receptor are being studied as candidates for the susceptibility to develop T2DM. Also, 1 is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop T2DM. The aim of the current study was to determine the relationship between (59029A/G) and 1 (rs10498210) polymorphisms with T2DM in Sanandajian patients. Genomic DNA was isolated from 200 healthy individuals and 220 Kurdish T2DM patients by salt extraction method and the polymorphisms were examined by restriction fragment length polymorphism (RFLP) method and then the results were analyzed using Chi-square test. The frequency of AA genotype in 220 Kurdish patients for both genes (OR=1.9, =0.02) and (OR [95% CI]=2.62, =0.02) were significantly more than controls. There was no significant association between AG or GG genotypes in with T2DM. The presence of AA homozygote alleles in both loci of (rs10498210) and (59029A/G) genes increased the risk of T2DM.
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S189170