Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis

Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in...

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Bibliographic Details
Published in:Egyptian Rheumatology and Rehabilitation 2023-03, Vol.50 (1), p.14-9, Article 14
Main Authors: Aboud, Fatma Mohammed, Galal, Salwa, Elwafa, Menna Allah Zakaria Abou, Farouk, ALshymaa Mohammed
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biological products
Blood
Blood diseases
Blood platelets
Cytokines
Females
Hematology
Hemoglobin
Lymphocytes
Males
Medicine
Medicine & Public Health
Neutropenia
Neutrophils
Psoriatic arthritis
Rehabilitation
Rheumatic diseases
Tumor necrosis factor-TNF
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Summary:Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts. Aim of this study The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis. Results One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics ( p  
ISSN:2090-3235
1110-161X
2090-3235
DOI:10.1186/s43166-023-00174-0