Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis

Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in...

Full description

Saved in:
Bibliographic Details
Published in:Egyptian Rheumatology and Rehabilitation 2023-03, Vol.50 (1), p.14-9, Article 14
Main Authors: Aboud, Fatma Mohammed, Galal, Salwa, Elwafa, Menna Allah Zakaria Abou, Farouk, ALshymaa Mohammed
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biological products
Blood
Blood diseases
Blood platelets
Cytokines
Females
Hematology
Hemoglobin
Lymphocytes
Males
Medicine
Medicine & Public Health
Neutropenia
Neutrophils
Psoriatic arthritis
Rehabilitation
Rheumatic diseases
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383
cites cdi_FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383
container_end_page 9
container_issue 1
container_start_page 14
container_title Egyptian Rheumatology and Rehabilitation
container_volume 50
creator Aboud, Fatma Mohammed
Galal, Salwa
Elwafa, Menna Allah Zakaria Abou
Farouk, ALshymaa Mohammed
description Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts. Aim of this study The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis. Results One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics ( p  
doi_str_mv 10.1186/s43166-023-00174-0
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_6d742bd2ef624211b629d1bf967e001e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_6d742bd2ef624211b629d1bf967e001e</doaj_id><sourcerecordid>2780614746</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383</originalsourceid><addsrcrecordid>eNp9kstu1DAUhiMEElXbF2BliXXAt_iyQUIVl5EqsSlry_El4yGxg-0BzSvw1LiTqrQbVsc65_8_-1h_171B8B1Cgr0vlCDGeohJDyHitIcvugsMJewJJsPLJ-fX3XUpB9hUA4MCkovuz25ZtakgeTCGNKcpGD0DHS2IKfZPWjU7XRcXmzSCvVt0fRyFaINxpVWw6hqapoDfoe4b5sdpTiXECZQ1RXuaQw3lTF9LyqGJDdC57vN9_6p75fVc3PVDvey-f_50d_O1v_32ZXfz8bY3VNDaG2K4xhgjadggBZPQY8ep1KMxTgjEoKTGaiu00YMQnntnqeTIeA7HgQhy2e02rk36oNYcFp1PKumgzo2UJ9XeFMzsFLOc4tFi5xmmGKGRYWnR6CXjrn2ia6wPG2s9jouzpu2e9fwM-nwSw15N6ZeSklMiaQO8fQDk9PPoSlWHdMyx7a8wF5AhyilrKrypTE6lZOcfb0BQ3WdAbRlQLQPqnAEFm4lsptLEcXL5H_o_rr-_77iz</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2780614746</pqid></control><display><type>article</type><title>Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis</title><source>Publicly Available Content Database</source><source>Coronavirus Research Database</source><source>Springer Nature - Springer Nature Link Journals - Fully Open Access</source><creator>Aboud, Fatma Mohammed ; Galal, Salwa ; Elwafa, Menna Allah Zakaria Abou ; Farouk, ALshymaa Mohammed</creator><creatorcontrib>Aboud, Fatma Mohammed ; Galal, Salwa ; Elwafa, Menna Allah Zakaria Abou ; Farouk, ALshymaa Mohammed</creatorcontrib><description>Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts. Aim of this study The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis. Results One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics ( p  &lt; 0.006), where there was a statistically highly significant increase in Hb (hemoglobin)/RDW ratio and Hb/platelets ratio at the biologics group than non-biologics ( p  &lt; 0.005). Conclusion As a result, biologic drugs used in rheumatology practice may have some effects on hematological parameters. In our study, no major negative effects on hematological parameters were observed in patients with AS and PsA who received Secukinumab, Adalimumab-atto, or Golimumab biologic therapy. However, the changes in the hematological indices correlates with their potent anti-inflammatory action in rheumatic patients.</description><identifier>ISSN: 2090-3235</identifier><identifier>ISSN: 1110-161X</identifier><identifier>EISSN: 2090-3235</identifier><identifier>DOI: 10.1186/s43166-023-00174-0</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autoimmune diseases ; Biological products ; Blood ; Blood diseases ; Blood platelets ; Cytokines ; Females ; Hematology ; Hemoglobin ; Lymphocytes ; Males ; Medicine ; Medicine &amp; Public Health ; Neutropenia ; Neutrophils ; Psoriatic arthritis ; Rehabilitation ; Rheumatic diseases ; Tumor necrosis factor-TNF</subject><ispartof>Egyptian Rheumatology and Rehabilitation, 2023-03, Vol.50 (1), p.14-9, Article 14</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383</citedby><cites>FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383</cites><orcidid>0000-0002-5010-2959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2780614746?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2780614746?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml></links><search><creatorcontrib>Aboud, Fatma Mohammed</creatorcontrib><creatorcontrib>Galal, Salwa</creatorcontrib><creatorcontrib>Elwafa, Menna Allah Zakaria Abou</creatorcontrib><creatorcontrib>Farouk, ALshymaa Mohammed</creatorcontrib><title>Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis</title><title>Egyptian Rheumatology and Rehabilitation</title><addtitle>Egypt Rheumatol Rehabil</addtitle><description>Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts. Aim of this study The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis. Results One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics ( p  &lt; 0.006), where there was a statistically highly significant increase in Hb (hemoglobin)/RDW ratio and Hb/platelets ratio at the biologics group than non-biologics ( p  &lt; 0.005). Conclusion As a result, biologic drugs used in rheumatology practice may have some effects on hematological parameters. In our study, no major negative effects on hematological parameters were observed in patients with AS and PsA who received Secukinumab, Adalimumab-atto, or Golimumab biologic therapy. However, the changes in the hematological indices correlates with their potent anti-inflammatory action in rheumatic patients.</description><subject>Autoimmune diseases</subject><subject>Biological products</subject><subject>Blood</subject><subject>Blood diseases</subject><subject>Blood platelets</subject><subject>Cytokines</subject><subject>Females</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Lymphocytes</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neutropenia</subject><subject>Neutrophils</subject><subject>Psoriatic arthritis</subject><subject>Rehabilitation</subject><subject>Rheumatic diseases</subject><subject>Tumor necrosis factor-TNF</subject><issn>2090-3235</issn><issn>1110-161X</issn><issn>2090-3235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstu1DAUhiMEElXbF2BliXXAt_iyQUIVl5EqsSlry_El4yGxg-0BzSvw1LiTqrQbVsc65_8_-1h_171B8B1Cgr0vlCDGeohJDyHitIcvugsMJewJJsPLJ-fX3XUpB9hUA4MCkovuz25ZtakgeTCGNKcpGD0DHS2IKfZPWjU7XRcXmzSCvVt0fRyFaINxpVWw6hqapoDfoe4b5sdpTiXECZQ1RXuaQw3lTF9LyqGJDdC57vN9_6p75fVc3PVDvey-f_50d_O1v_32ZXfz8bY3VNDaG2K4xhgjadggBZPQY8ep1KMxTgjEoKTGaiu00YMQnntnqeTIeA7HgQhy2e02rk36oNYcFp1PKumgzo2UJ9XeFMzsFLOc4tFi5xmmGKGRYWnR6CXjrn2ia6wPG2s9jouzpu2e9fwM-nwSw15N6ZeSklMiaQO8fQDk9PPoSlWHdMyx7a8wF5AhyilrKrypTE6lZOcfb0BQ3WdAbRlQLQPqnAEFm4lsptLEcXL5H_o_rr-_77iz</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Aboud, Fatma Mohammed</creator><creator>Galal, Salwa</creator><creator>Elwafa, Menna Allah Zakaria Abou</creator><creator>Farouk, ALshymaa Mohammed</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5010-2959</orcidid></search><sort><creationdate>20230301</creationdate><title>Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis</title><author>Aboud, Fatma Mohammed ; Galal, Salwa ; Elwafa, Menna Allah Zakaria Abou ; Farouk, ALshymaa Mohammed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autoimmune diseases</topic><topic>Biological products</topic><topic>Blood</topic><topic>Blood diseases</topic><topic>Blood platelets</topic><topic>Cytokines</topic><topic>Females</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Lymphocytes</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Neutropenia</topic><topic>Neutrophils</topic><topic>Psoriatic arthritis</topic><topic>Rehabilitation</topic><topic>Rheumatic diseases</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aboud, Fatma Mohammed</creatorcontrib><creatorcontrib>Galal, Salwa</creatorcontrib><creatorcontrib>Elwafa, Menna Allah Zakaria Abou</creatorcontrib><creatorcontrib>Farouk, ALshymaa Mohammed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Hospital Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Rheumatology and Rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aboud, Fatma Mohammed</au><au>Galal, Salwa</au><au>Elwafa, Menna Allah Zakaria Abou</au><au>Farouk, ALshymaa Mohammed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis</atitle><jtitle>Egyptian Rheumatology and Rehabilitation</jtitle><stitle>Egypt Rheumatol Rehabil</stitle><date>2023-03-01</date><risdate>2023</risdate><volume>50</volume><issue>1</issue><spage>14</spage><epage>9</epage><pages>14-9</pages><artnum>14</artnum><issn>2090-3235</issn><issn>1110-161X</issn><eissn>2090-3235</eissn><abstract>Background Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts. Aim of this study The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis. Results One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics ( p  &lt; 0.006), where there was a statistically highly significant increase in Hb (hemoglobin)/RDW ratio and Hb/platelets ratio at the biologics group than non-biologics ( p  &lt; 0.005). Conclusion As a result, biologic drugs used in rheumatology practice may have some effects on hematological parameters. In our study, no major negative effects on hematological parameters were observed in patients with AS and PsA who received Secukinumab, Adalimumab-atto, or Golimumab biologic therapy. However, the changes in the hematological indices correlates with their potent anti-inflammatory action in rheumatic patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43166-023-00174-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5010-2959</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-3235
ispartof Egyptian Rheumatology and Rehabilitation, 2023-03, Vol.50 (1), p.14-9, Article 14
issn 2090-3235
1110-161X
2090-3235
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_6d742bd2ef624211b629d1bf967e001e
source Publicly Available Content Database; Coronavirus Research Database; Springer Nature - Springer Nature Link Journals - Fully Open Access
subjects Autoimmune diseases
Biological products
Blood
Blood diseases
Blood platelets
Cytokines
Females
Hematology
Hemoglobin
Lymphocytes
Males
Medicine
Medicine & Public Health
Neutropenia
Neutrophils
Psoriatic arthritis
Rehabilitation
Rheumatic diseases
Tumor necrosis factor-TNF
title Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-03-09T20%3A05%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20biological%20and%20non-biological%20treatment%20on%20hematological%20indices%20in%20patients%20with%20ankylosing%20spondylitis%20and%20psoriatic%20arthritis&rft.jtitle=Egyptian%20Rheumatology%20and%20Rehabilitation&rft.au=Aboud,%20Fatma%20Mohammed&rft.date=2023-03-01&rft.volume=50&rft.issue=1&rft.spage=14&rft.epage=9&rft.pages=14-9&rft.artnum=14&rft.issn=2090-3235&rft.eissn=2090-3235&rft_id=info:doi/10.1186/s43166-023-00174-0&rft_dat=%3Cproquest_doaj_%3E2780614746%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c484t-c3c7a22219c6598690f2e749abcce8816094cdad8aca588f7fed4971cf70b5383%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2780614746&rft_id=info:pmid/&rfr_iscdi=true