Uncommon vancomycin-induced side effects

Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the red man syndrome . Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2002-08, Vol.6 (4), p.196-200
Main Authors: Rocha, Jaime Luis Lopes, Kondo, William, Baptista, Maria Inêz Domingues Kuchiki, Da Cunha, Clovis Arns, Martins, Luzmila Terezinha Flenik
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - therapeutic use
Eosinophilia - chemically induced
Erythema - chemically induced
Female
Fever - chemically induced
Hip Prosthesis
Humans
INFECTIOUS DISEASES
Methicillin Resistance
Middle Aged
Neutropenia - chemically induced
Ofloxacin - therapeutic use
pancytopenia
Prosthesis-Related Infections - drug therapy
Pruritus - chemically induced
reactions
Staphylococcus - isolation & purification
Stevens-Johnson
Syndrome
thrombocytopenia
Vancomycin
Vancomycin - adverse effects
Vancomycin - therapeutic use
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Summary:Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the red man syndrome . Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two cases of vancomycin-induced Stevens-Johnson syndrome and one case of pancytopenia have been reported in the medical literature. The treatment for both situations is based on cessation of the vancomycin therapy; in cases of Stevens-Johnson syndrome, antihistamine and/or steroid agents can be used. This article reports a case of pancytopenia and a case of erythema major associated with neutropenia.
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1590/S1413-86702002000400007