Crosstalk between autophagy and metabolic regulation of cancer stem cells

Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cancer 2020-02, Vol.19 (1), p.27-27, Article 27
Main Authors: El Hout, Mouradi, Cosialls, Emma, Mehrpour, Maryam, Hamaï, Ahmed
Format: Article
Language:English
Subjects:
Animals
Autophagy
Cancer
Cancer stem cells
Cancer therapies
Ecosystems
Humans
Kinases
Lipid metabolism
Metabolic heterogeneity
Metabolic Networks and Pathways
Metabolic pathways
Metabolites
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Ovarian cancer
Phagocytosis
Phenotypes
Physiological aspects
Review
Stem cells
Therapeutic target
Tumor cells
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-019-1126-8