Advances in genetics: widening our understanding of prostate cancer

Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencin...

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Bibliographic Details
Published in:F1000 research 2016, Vol.5, p.1512
Main Authors: Pine, Angela C, Fioretti, Flavia F, Brooke, Greg N, Bevan, Charlotte L
Format: Article
Language:English
Subjects:
Bioinformatics
Cancer Therapeutics
Cell Growth & Division
Genito-Urinary & Reproductive Pharmacology
Genitourinary Cancers
Genomics
Medical Genetics
Nuclear Structure & Function
Precision medicine
Prostate cancer
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Summary:Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.8019.1