Trend analysis of the role of circular RNA in goat skeletal muscle development

Circular RNA (circRNA) is produced during the splicing of mRNA (in addition to linear splicing) and is part of the gene regulatory network. The temporal expression patterns the different developmental stages were inseparable from these molecules' function. Skeletal muscles of Anhui white goat (...

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Bibliographic Details
Published in:BMC genomics 2020-03, Vol.21 (1), p.220-220, Article 220
Main Authors: Ling, Yinghui, Zheng, Qi, Zhu, Lu, Xu, Lina, Sui, Menghua, Zhang, Yunhai, Liu, Ya, Fang, Fugui, Chu, Mingxing, Ma, Yuehui, Zhang, Xiaorong
Format: Article
Language:English
Subjects:
Actin
Biosynthesis
Chromosomes
circRNA
Circular RNA
Development
Developmental stages
Enzymatic activity
Enzymes
Fetuses
Genes
Genetic aspects
Genomics
Goats
Growth
Mammals
Messenger RNA
Methods
Muscle proteins
Muscles
Musculoskeletal system
Newborn infants
Nucleic acids
Principal components analysis
Protein binding
Ribonucleic acid
RNA
RNA sequencing
RNA-seq
Skeletal muscle
Trend analysis
Trends
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Summary:Circular RNA (circRNA) is produced during the splicing of mRNA (in addition to linear splicing) and is part of the gene regulatory network. The temporal expression patterns the different developmental stages were inseparable from these molecules' function. Skeletal muscles of Anhui white goat (AWG) across seven fetal to postnatal development stages were sequenced and 21 RNA sequencing libraries were constructed. We thereby identified 9090 circRNAs and analyzed their molecular properties, temporal expression patterns, and potential functions at the different stages. CircRNAs showed complexities and diversity of formation as the same host gene produces multiple isoforms of these nucleic acids with different expression profiles. The differential expression of 2881 circRNAs (DECs, P  2 and P-adj value 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-020-6649-2