Exogenous recombinant adiponectin improves survival in experimental abdominal sepsis

Adiponectin, which has anti-inflammatory features, is an important substance in several metabolic mechanisms. The aim of this study is to evauate the effects of exogenous intraperitoneal administration of adiponectin on the survival, intrabdominal adhesion and inflammatory cytokine levels in an expe...

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Bibliographic Details
Published in:Balkan medical journal 2014-09, Vol.31 (3), p.244-248
Main Authors: Salman, Bülent, Yılmaz, Tonguç Utku, Tezcaner, Tugan, Demir, Ebru Ofluoğlu, Paşaoğlu, Ozge Tuğçe
Format: Article
Language:English
Subjects:
Adhesion
adiponectin
cytokine
Original
sepsis
survival
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Summary:Adiponectin, which has anti-inflammatory features, is an important substance in several metabolic mechanisms. The aim of this study is to evauate the effects of exogenous intraperitoneal administration of adiponectin on the survival, intrabdominal adhesion and inflammatory cytokine levels in an experimental sepsis model. Animal experimentation. Ninety rats were divided into a control group, adiponectin group and sham group. A cecal puncture abdominal sepsis model was performed in the adiponectin and control groups. Every three hours, exogenous adiponectin was administrated to the adiponectin group. At the 3(rd) and 24(th) hours, 10 rats were sacrified in each group in order to measure plasma tumor necrosis factor-α (TNF-α), interleukin (IL) 10, soluble intracellular adhesion molecule (ICAM)-1, IL-6 and macrophage inhibitory factor levels, and the activity of nuclear factor (NF)-kB. The remaining rats were followed for survival. The plasma levels of TNF-α, soluable ICAM-1, IL-6, and macrophage inhibitory factor were significantly higher in the control group than in the adiponectin and sham group (p
ISSN:2146-3123
2146-3131
DOI:10.5152/balkanmedj.2014.13202