Factors related to the mortality risk of severe hand, foot, and mouth diseases (HFMD): a 5-year hospital-based survey in Guangxi, Southern China

• Published in: BMC infectious diseases 2023-03, Vol.23 (1), p.144-144, Article 144
• Main Authors: Peng, Yuanjun, He, Weitao, Zheng, Zhigang, Pan, Peijiang, Ju, Yu, Lu, Zhenwei, Liao, Yanyan, Wang, Hailong, Zhang, Chao, Wang, Jing, Jiang, Lina, Liang, Hao, Chen, Minmei, Ye, Li
• Format: Article
• Language: English
• Subjects: Care and treatment; Child; China; China - epidemiology; Clinical outcomes; Coxsackievirus infections; Cyanosis; Death; Demographics; Development and progression; Disease prevention; Edema; Encephalitis; Enterovirus; Enterovirus A, Human; Epidemiology; EV-A71 vaccination; Exanthema; FDA approval; Females; Forecasts and trends; Hand, foot and mouth disease; Hand, Foot and Mouth Disease - epidemiology; Health risks; Hospitals; Humans; Immunization; Infant; Influencing factors; Licenses; Logistics; Meningitis; Methods; Mortality; Mortality risk; Mouth; Mouth Diseases; Multivariate analysis; Nervous system; Outcome; Patients; Prevention; Questionnaires; Regression analysis; Regression models; Risk factors; Severe cases; Signs and symptoms; Software; Surveys; Vaccination; Vaccines; Variables
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-023-08109-y

To understand the factors influencing clinical outcomes of severe hand, foot, and mouth diseases (HFMD), and to provide scientific evidence for reducing the mortality risk of severe HFMD. From 2014 to 2018, children diagnosed with severe HFMD cases in Guangxi, China, were enrolled in this hospital-based study. The epidemiological data obtained through face-to-face interviews with the parents and guardians. Univariate and multivariate logistics regression models were used to analyze the factors influencing the clinical outcomes of severe HFMD. The impact of the EV-A71 vaccination on inpatient mortality was analyzed by a comparison approach. A total of 1565 severe HFMD cases were enrolled in this survey, including 1474 (94.19%) survival cases and 91 (5.81%) death cases. The multivariate logistic analysis demonstrated that HFMD history of playmates in the last three months, first visit to the village hospital, time from the first visit to admission less than two days, no correct diagnosis for HFMD at the first visit, and having no rash symptoms were the independent risk factors for severe HFMD cases (all p