Management of Uncontrolled Asthma: A Framework for Novel and Legacy Biologic Treatments

Asthma continues to be a complex respiratory disease to control for many despite optimal standard inhaler therapy. The increased dependence on steroid-sparing biologic treatments in the 21st century has created a dilemma between identifying the patient's intrinsic biomarkers and their "lif...

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Bibliographic Details
Published in:Journal of asthma and allergy 2022-01, Vol.15, p.875-883
Main Authors: Tan, Laren D, Nguyen, Nolan, Alismail, Abdullah, Castro, Mario
Format: Article
Language:English
Subjects:
Allergens
Allergies
Asthma
asthma biologic
B cells
Biological products
Care and treatment
Clinical decision making
Cytokines
Decision making
Disease
Drug approval
Evidence-based medicine
Inflammation
Inhalers
Monoclonal antibodies
Pathogenesis
Pathophysiology
Patients
Respiration
Respiratory agents
Respiratory diseases
Review
severe asthma
shared decision making
Steroids
tezepelumab
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Summary:Asthma continues to be a complex respiratory disease to control for many despite optimal standard inhaler therapy. The increased dependence on steroid-sparing biologic treatments in the 21st century has created a dilemma between identifying the patient's intrinsic biomarkers and their "life markers." With Tezepelumab being the most recent FDA-approved biologic for asthma, it is even more critical for asthma specialists to better understand and establish a framework to determine which biologic would work best for their patients. While cost and payor approvals limit access to certain asthma biologics, medical decisions on which biologic to select should be centered around shared decision-making, the rationale for biologic initiation, and critical biologic education to help achieve successful asthma control. Keywords: severe asthma, Tezepelumab, asthma biologic, shared decision making, asthma
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S369836