Iron Deficiency Anemia in Inflammatory Bowel Diseases-A Narrative Review

• Published in: Nutrients 2021-11, Vol.13 (11), p.4008
• Main Authors: Mahadea, Dagmara, Adamczewska, Ewelina, Ratajczak, Alicja Ewa, Rychter, Anna Maria, Zawada, Agnieszka, Eder, Piotr, Dobrowolska, Agnieszka, Krela-Kaźmierczak, Iwona
• Format: Article
• Language: English
• Subjects: Administration, Intravenous; Anemia; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - complications; Anemia, Iron-Deficiency - drug therapy; Blood; C-Reactive Protein; Chronic illnesses; Colitis, Ulcerative; Complications; Conjunctiva; Crohn Disease - blood; Crohn's disease; Cytokines; dietary factors; Dietary Supplements; dysbiosis; Fatigue; Female; Gastrointestinal system; Gastrointestinal tract; Guidelines; Hemoglobin; Homeostasis; Humans; Hypoxia; IBD; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - drug therapy; Intestinal microflora; Intestine; Intravenous administration; Iron; Iron - blood; Iron - metabolism; Iron - therapeutic use; Iron Deficiencies; iron deficiency; Malabsorption; Male; Metabolism; Microbiota; Mucosa; Nutrient deficiency; Pathogenesis; Patients; Quality of Life; Review; Signs and symptoms; Systematic review; Tumor necrosis factor-TNF; Ulcerative colitis
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13114008

Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. IBD has been associated with numerous symptoms and complications, with the most common being iron deficiency anemia (IDA). Iron deficiency in IBD is caused by inadequate intake, malabsorption (including duodenal involvement and surgical removal), and chronic blood loss by mucosal ulcerations. Therefore, an appropriate diet should be enforced. Iron deficiency and iron supplementation have been associated with alterations to gut microbiota. IBD-associated anemia, in particular iron deficiency anemia, is associated with a significant decrease in quality of life and with clinical symptoms such as chronic fatigue, headaches and dizziness, reduced exercise tolerance, pale skin, nails, conjunctiva, and fainting. However, despite these numerous adverse symptoms, IDA remains undertreated. The European Crohn's and Colitis Organisation (ECCO) guidelines state that patients should be monitored for anemia. Adequate treatment, whether oral or intravenous, should be implemented while taking into consideration C-reactive protein values (CRP), hemoglobin levels, and therapeutic response. It should be stressed that every case of anemia in IBD patients should be treated. Intravenous iron formulations, which are more superior compared to the oral form, should be used. There is a need to increase awareness and implementation of international guidelines on iron supplementation in patients with IBD.