The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

( ), the etiological agent of human tuberculosis (TB), has plagued humans for thousands of years. TB still remains a major public health problem in our era, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling -contaminated aerosols, TB primo-infection...

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Bibliographic Details
Published in:Frontiers in microbiology 2017-11, Vol.8, p.2284-2284
Main Authors: Queval, Christophe J, Brosch, Roland, Simeone, Roxane
Format: Article
Language:English
Subjects:
Bacteriology
Cell Behavior
cell death
Cellular Biology
cytosolic access
Genetics
Human genetics
Human health and pathology
Infectious diseases
Life Sciences
macrophages
Microbiology
Microbiology and Parasitology
Mycobacterium tuberculosis
phagosome maturation
Pulmonology and respiratory tract
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Summary:( ), the etiological agent of human tuberculosis (TB), has plagued humans for thousands of years. TB still remains a major public health problem in our era, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling -contaminated aerosols, TB primo-infection starts in the terminal lung airways, where is taken up by alveolar macrophages. Although macrophages are known as professional killers for pathogens, has adopted remarkable strategies to circumvent host defenses, building suitable conditions to survive and proliferate. Within macrophages, initially resides inside phagosomes, where its survival mostly depends on its ability to take control of phagosomal processing, through inhibition of phagolysosome biogenesis and acidification processes, and by progressively getting access to the cytosol. Bacterial access to the cytosolic space is determinant for specific immune responses and cell death programs, both required for the replication and the dissemination of . Comprehension of the molecular events governing survival within macrophages is fundamental for the improvement of vaccine-based and therapeutic strategies in order to help the host to better defend itself in the battle against the fierce invader . In this mini-review, we discuss recent research exploring how conquers and transforms the macrophage into a strategic base for its survival and dissemination as well as the associated defense strategies mounted by host.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2017.02284