Impact of a personal history of cutaneous squamous cell carcinoma in the overall survival of cutaneous melanoma patients

Background There have been previous studies on the association between cutaneous squamous cell carcinoma (cSCC) and cutaneous melanoma (CM) survival, and also the association between skin cancers and relative telomere length (RTL). In this study we analysed the overall survival (OS) of patients with...

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Published in:JEADV clinical practice 2022-06, Vol.1 (2), p.96-104
Main Authors: Moro, Ruggero, Campos, Eva, González‐Cuevas, Rubén, Aguerralde‐Martin, Maider, Requena, Celia, Manrique‐Silva, Esperanza, Traves, Victor, Virós, Amaya, Kumar, Rajiv, Nagore, Eduardo
Format: Article
Language:English
Subjects:
Age
Contingency tables
Hypotheses
Medical prognosis
Melanoma
Metastasis
Patients
Senescence
Skin cancer
Squamous cell carcinoma
survival
Telomerase
telomere length
Tumors
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Summary:Background There have been previous studies on the association between cutaneous squamous cell carcinoma (cSCC) and cutaneous melanoma (CM) survival, and also the association between skin cancers and relative telomere length (RTL). In this study we analysed the overall survival (OS) of patients with CM and a positive history of cSCC to evaluate the impact of this history on survival and any possible association with RTL. Materials and Methods A retrospective cohort study on 1613 patients with CM diagnosed between 1 January 2000 and 31 December 2015 at the Instituto Valenciano de Oncología. Contingency tables were used to analyze the association between a positive history of cSCC and other covariates. OS was evaluated using Kaplan–Meier curves and log‐rank test. Cox regression was used to determine the prognostic role of each covariate. Results Patients with a positive history of cSCC had a shorter OS (p 
ISSN:2768-6566
2768-6566
DOI:10.1002/jvc2.18