EFFECT OF AN ANTI-INFLAMMATORY DRUG (PIROXICAM) ON SOME BIOCHEMICAL FACTORS AND DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

ABSTRACT Objective: To investigate the effect of an anti-inflammatory drug (Piroxicam) on the development of fatty streak in rabbits. Methods: Male rabbits were fed with four types of regimen: a) normal rabbit chow, b) 1% cholesterol diet c) cholesterol diet plus Piroxicam, d) normal rabbit chow plu...

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Bibliographic Details
Published in:ARYA atherosclerosis 2010-12, Vol.1 (1)
Main Authors: Sedigheh Asgary, Gholam-Ali Naderi, Gholam-Reza Dashti, Zamzam Paknahad
Format: Article
Language:English
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Summary:ABSTRACT Objective: To investigate the effect of an anti-inflammatory drug (Piroxicam) on the development of fatty streak in rabbits. Methods: Male rabbits were fed with four types of regimen: a) normal rabbit chow, b) 1% cholesterol diet c) cholesterol diet plus Piroxicam, d) normal rabbit chow plus Piroxicam. After 12 weeks, the animals were sacrificed and the aorta, as well as the right and left branches of the coronary artery were dissected, and histological processing was carried out. Samples were observed under light microscope with different magnifications. Some biochemical tests were measured before and after the treatment. Results: A significant difference was found between the two groups receiving Piroxicam-supplemented diet and the two others (p
ISSN:1735-3955
2251-6638