Antiphotoaging effects of solvent fractions isolated from Allomyrina dichotoma larvae extract

Skin aging is affected by a variety of factors, including ultraviolet rays, oxidative stress, medications, smoking, and genetics. Among them, photo-aging accounts for about 80% of skin aging. The present study was evaluated to verify the potential of Allomyrina dichotoma larvae, which has recently b...

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Bibliographic Details
Published in:Biochemistry and biophysics reports 2024-07, Vol.38, p.101660-101660, Article 101660
Main Authors: Kim, Kyong, Park, Eun-Young, Baek, Dong-Jae, Lee, Chang-Seok, Oh, Yoon Sin
Format: Article
Language:English
Subjects:
Allomyrina dichotoma larvae
Collagen
Human dermal fibroblast
Photo-aging
Short Communication
Ultraviolet B
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Summary:Skin aging is affected by a variety of factors, including ultraviolet rays, oxidative stress, medications, smoking, and genetics. Among them, photo-aging accounts for about 80% of skin aging. The present study was evaluated to verify the potential of Allomyrina dichotoma larvae, which has recently been attracting attention as an edible insect, as an anti-aging substance. UVB irradiation at 100 mJ/cm2 was sufficient to induce photo-aging of fibroblasts within 24 h, which was alleviated after treatment with 70% ethanol extract of Allomyrina dichotoma larvae extract (ADLE). To obtain an extract from ADLE, which has a relatively high content of polyphenol compounds containing physiological activity, fractional solvent extraction was carried out using organic solvents such as hexane, chloroform, ethyl acetate, and butanol. Additionally, ethyl acetate and butanol fractions contributed to the inhibition of UVB-induced ROS production, cell damage, and senescence of fibroblasts. It was also confirmed that the two fractions can regulate the expression of MMP-1 and AP-1. In particular, the ethyl acetate fraction showed an excellent effect in recovering collagen decomposed by UVB. Therefore, these results suggest that ADLE has potential as a natural insect-derived biomaterial to inhibit UVB-induced photo-aging. •UVB irradiation induces skin photoaging.•ADLE alleviates photo-aging in UVB-induced HDF cells.•The polyphenol rich-ethyl acetate fraction of ADLE prevents collagen degradation.•The ethyl acetate fraction of ADLE may be a potential skin anti-photoaging agent.
ISSN:2405-5808
2405-5808
DOI:10.1016/j.bbrep.2024.101660