Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions

This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step manufacturing of ASD is possible using selective laser sintering...

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Bibliographic Details
Published in:Pharmaceutics 2021-07, Vol.13 (8), p.1149
Main Authors: Thakkar, Rishi, Jara, Miguel O, Swinnea, Steve, Pillai, Amit R, Maniruzzaman, Mohammed
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Aluminum
amorphous solid dispersion
Drug dosages
Laser sintering
laser speed
Manufacturing
Particle size
Pharmaceuticals
Polymers
Rapid prototyping
Raw materials
residual crystallinity
selective laser sintering
Silica
Solids
solubility enhancement
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Summary:This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step manufacturing of ASD is possible using selective laser sintering 3D printing processes, however, the mechanism of ASD formation by this process is not completely understood and it requires further investigation. We hypothesize that the mechanism of ASD formation is the diffusion and dissolution of the drug in the polymeric carrier during the selective laser sintering (SLS) process and the drug particle size plays a critical role in the formation of said ASDs as there is no mixing involved in the sintering process. Herein, indomethacin was used as a model drug and introduced into the feedstock (Kollidon VA64 and Candurin blend) as either unprocessed drug crystals (particle size > 50 µm) or processed hot-melt extruded granules (DosePlus) with reduced drug particle size (
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13081149