Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients

• Published in: Lipids in health and disease 2017-08, Vol.16 (1), p.154-154, Article 154
• Main Authors: Hadj Ahmed, Samia, Kaoubaa, Nadia, Kharroubi, Wafa, Zarrouk, Amira, Najjar, Mohamed Fadhel, Batbout, Fathi, Gamra, Habib, Lizard, Gerard, Hammami, Mohamed
• Format: Article
• Language: English
• Subjects: Aged; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Case-Control Studies; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - physiopathology; Coronary heart disease; Desaturation index; Development and progression; Erucic Acids - blood; Fatty acid profile; Fatty acids; Fatty Acids - blood; Fatty Acids - classification; Female; Gensini score; Humans; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Lipoproteins, VLDL - blood; Male; Middle Aged; Physiological aspects; Severity of Illness Index; Stearic Acids - blood; Triglycerides - blood; Tunisia
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-017-0538-y

Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls. CAD patients showed an alteration of conventional lipid parameters. In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p