ASSOCIATION OF ALLELE VARIANTS OF RECEPTOR GENE OF ANDROGENS (BY THE NUMBER OF CAG-REPEATS) WITH ANDROGEN DEPENDENT HORMONAL METABOLIC INDICES OF THE ORGANISM

This review discusses up-to-date conceptions concerning an association of androgen receptor gene (AR) allele (by the number of CAG-repeats) variations with the change of the receptor activity in humans. Different contradictory experiment results concerning the AR function dependence on the number of...

Full description

Saved in:
Bibliographic Details
Published in:Ukrainian biochemical journal 2015-04, Vol.87 (2), p.26-40
Main Authors: Korpachev, V V, Melnychenko, S V, Lukashova, R G
Format: Article
Language:eng ; ukr
Subjects:
Alleles
Estradiol - metabolism
Female
Gene Expression Regulation
Glucose - metabolism
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Humans
Lipid Metabolism
Male
Protein Multimerization
Receptors, Androgen - chemistry
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Sex Factors
Signal Transduction
Testosterone - metabolism
Trinucleotide Repeats
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This review discusses up-to-date conceptions concerning an association of androgen receptor gene (AR) allele (by the number of CAG-repeats) variations with the change of the receptor activity in humans. Different contradictory experiment results concerning the AR function dependence on the number of CAG-repeats have been analyzed. The authors discuss this problem paying mostly their attention to the interrelation between the number of CAG-repeats and indicators of glucose and lipid metabolism in males and females.
ISSN:2409-4943
2413-5003
DOI:10.15407/ubj87.02.026