ASSOCIATION OF ALLELE VARIANTS OF RECEPTOR GENE OF ANDROGENS (BY THE NUMBER OF CAG-REPEATS) WITH ANDROGEN DEPENDENT HORMONAL METABOLIC INDICES OF THE ORGANISM

This review discusses up-to-date conceptions concerning an association of androgen receptor gene (AR) allele (by the number of CAG-repeats) variations with the change of the receptor activity in humans. Different contradictory experiment results concerning the AR function dependence on the number of...

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Published in:Ukrainian biochemical journal 2015-04, Vol.87 (2), p.26-40
Main Authors: Korpachev, V V, Melnychenko, S V, Lukashova, R G
Format: Article
Language:eng ; ukr
Subjects:
Alleles
Estradiol - metabolism
Female
Gene Expression Regulation
Glucose - metabolism
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Humans
Lipid Metabolism
Male
Protein Multimerization
Receptors, Androgen - chemistry
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Sex Factors
Signal Transduction
Testosterone - metabolism
Trinucleotide Repeats
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container_title Ukrainian biochemical journal
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creator Korpachev, V V
Melnychenko, S V
Lukashova, R G
description This review discusses up-to-date conceptions concerning an association of androgen receptor gene (AR) allele (by the number of CAG-repeats) variations with the change of the receptor activity in humans. Different contradictory experiment results concerning the AR function dependence on the number of CAG-repeats have been analyzed. The authors discuss this problem paying mostly their attention to the interrelation between the number of CAG-repeats and indicators of glucose and lipid metabolism in males and females.
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source IngentaConnect Journals
subjects Alleles
Estradiol - metabolism
Female
Gene Expression Regulation
Glucose - metabolism
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Humans
Lipid Metabolism
Male
Protein Multimerization
Receptors, Androgen - chemistry
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Sex Factors
Signal Transduction
Testosterone - metabolism
Trinucleotide Repeats
title ASSOCIATION OF ALLELE VARIANTS OF RECEPTOR GENE OF ANDROGENS (BY THE NUMBER OF CAG-REPEATS) WITH ANDROGEN DEPENDENT HORMONAL METABOLIC INDICES OF THE ORGANISM
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