Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults

• Published in: Nutrients 2023-01, Vol.15 (2), p.370
• Main Authors: León-Reyes, Guadalupe, Argoty-Pantoja, Anna D, Rivera-Paredez, Berenice, Hidalgo-Bravo, Alberto, Flores, Yvonne N, Salmerón, Jorge, Velázquez-Cruz, Rafael
• Format: Article
• Language: English
• Subjects: ABCA1 protein; Adult; Adults; Alleles; ATP Binding Cassette Transporter 1 - genetics; ATP-binding protein; Blood; Blood pressure; Body fat; Body mass index; Carbohydrates; Cholesterol; Cholesterol, HDL; Cohort analysis; Cohort Studies; Diet; Disease; DNA methylation; Female; Genes; Genetic diversity; Genetic variance; gene–diet interaction; gene–gene interaction; Genotyping; Health care; High density lipoprotein; Humans; Hypertension; hypoalphalipoproteinemia; Lipid metabolism; Lipids; Medical personnel; Metabolic disorders; Nucleotide Transport Proteins - genetics; Nutrients; Nutrition research; Polymorphism; Polyunsaturated fatty acids; Population; Preventive medicine; Questionnaires; rs17120425; rs1784042; rs9282541; Serum levels; Software; Statistical power
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15020370

Previous studies have reported that the and genes are involved in lipid metabolism. We aimed to analyze the association-the gene x gene interaction between rs17120425 and rs1784042 on and rs9282541 on and their diet interaction on the HDL-c serum levels-in a cohort of 1982 Mexican adults from the Health Workers Cohort Study. Demographic and clinical data were collected through a structured questionnaire and standardized procedures. Genotyping was performed using a predesigned TaqMan assay. The associations and interactions of interest were estimated using linear and logistic regression. Carriers of the rs17120425-A and rs1784042-A alleles had slightly higher blood HDL-c levels compared to the non-carriers. In contrast, rs9282541-A was associated with low blood HDL-c levels (OR = 1.34, = 0.013). The rs1784042 x rs9282541 interaction was associated with high blood HDL-c levels ( = 3.4 × 10 ). Premenopausal women who carried at least one rs17120425-A allele and consumed high dietary fat, protein, monounsaturated, or polyunsaturated fatty acids levels had higher HDL-c levels than the non-carriers. These results support the association between the genetic variants on and with HDL-c levels and suggest gene-gene and gene-diet interactions over HDL-c concentrations in Mexican adults. Our findings could be a platform for developing clinical and dietary strategies for improving the health of the Mexican population.