Evaluation of EBNA-1 (epstein-barr virus nuclear antigen-1) gene prevalence in nasopharyngeal carcinoma in Vietnamese patients

This study examined the presence of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) based on the detection of EBNA-1 (Epstein-Barr virus nuclear antigen-1) by Polymerase Chain Reaction (PCR), in Vietnamese population. Firstly, we systematically analyzed the mean of percentage weighted of...

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Bibliographic Details
Published in:Ho Chi Minh City Open University Journal of Science - Engineering and Technology (Online) 2016-03, Vol.6 (1), p.3-10
Main Authors: Lao Duc Thuan, Nguyen Hoang Anh Tuan, Ngo Dong Kha, Thieu Hong Hue, Ho Ta Giap, Nguyen Hai Chau, Nguyen Huu Dung, Le Huyen Ai Thuy
Format: Article
Language:English
Subjects:
ebna-1
nasopharyngeal carcinoma
vietnamese population
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Summary:This study examined the presence of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) based on the detection of EBNA-1 (Epstein-Barr virus nuclear antigen-1) by Polymerase Chain Reaction (PCR), in Vietnamese population. Firstly, we systematically analyzed the mean of percentage weighted of the presence of EBNA-1 in previous relevant studies. Experimentally, 31 nasopharyngeal cancer biopsies and 20 healthy samples were enrolled in current to evaluate the frequency of candidate genes. As the results, the frequency of EBNA-1 was 77.42%, whereas, none of any cases of healthy samples were found to positive to target gene. The p value < 0.05 (p = 0.0001) showed that it was significant correlation between the presence of this candidate gene and nasopharyngeal cancer. Moreover, a high odds ratio (OR) and relative risk (RR) of candidate gene, (OR = 68.16, RR = 2.41) were calculated. Therefore, the detection of EBNA-1, which performed by PCR, could serve as a good supplement to early diagnosis and prognosis of NPC in Vietnamese population.
ISSN:2734-9330
2734-9608