The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study

Exhaled volatile organic compounds (VOCs) are of interest due to their minimally invasive sampling procedure. Previous studies have investigated the impact of exercise, with evidence suggesting that breath VOCs reflect exercise-induced metabolic activity. However, these studies have yet to investiga...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (2), p.370
Main Authors: Heaney, Liam M, Kang, Shuo, Turner, Matthew A, Lindley, Martin R, Thomas, C L Paul
Format: Article
Language:English
Subjects:
Adult
Breath Tests - methods
Butadienes - analysis
Desorption
Exercise
Exercise - physiology
Exercise Test - methods
Exhalation - physiology
exhaled breath
Female
Gas chromatography
Gas Chromatography-Mass Spectrometry
Hemiterpenes - analysis
Humans
Isoprene
Male
Mass spectrometry
Mass spectroscopy
Medical research
Metabolites
metabolomics
Organic compounds
Oxygen consumption
Pentanes - analysis
Physical fitness
Pilot Projects
Statistical analysis
Statistical methods
VOCs
Volatile organic compounds
Volatile Organic Compounds - analysis
Young Adult
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Summary:Exhaled volatile organic compounds (VOCs) are of interest due to their minimally invasive sampling procedure. Previous studies have investigated the impact of exercise, with evidence suggesting that breath VOCs reflect exercise-induced metabolic activity. However, these studies have yet to investigate the impact of maximal exercise to exhaustion on breath VOCs, which was the main aim of this study. Two-litre breath samples were collected onto thermal desorption tubes using a portable breath collection unit. Samples were collected pre-exercise, and at 10 and 60 min following a maximal exercise test (VO ). Breath VOCs were analysed by thermal desorption-gas chromatography-mass spectrometry using a non-targeted approach. Data showed a tendency for reduced isoprene in samples at 10 min post-exercise, with a return to baseline by 60 min. However, inter-individual variation meant differences between baseline and 10 min could not be confirmed, although the 10 and 60 min timepoints were different ( = 0.041). In addition, baseline samples showed a tendency for both acetone and isoprene to be reduced in those with higher absolute VO scores (mL(O )/min), although with restricted statistical power. Baseline samples could not differentiate between relative VO scores (mL(O )/kg/min). In conclusion, these data support that isoprene levels are dynamic in response to exercise.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27020370