Neurotropic action of soy lecithin in the process of cognitive function formation in white rats

In experiments conducted on white rats neurotropic action of soy lecithin, known as a source of unsaturated fatty acids on the background of the neurotoxic impact of CCl4was studied. Useage of CCl4by courses showed a significant inhibitory effect that affected the spontaneous behavior of rats “in th...

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Bibliographic Details
Published in:Medychni perspektyvy 2015-01, Vol.20 (1), p.4-9
Main Authors: Drozdov, A L, Rodinsky, А G, Zubkovskaya, А G, Demchenko, Е М, Romanenko, L A
Format: Article
Language:eng ; rus ; ukr
Subjects:
Cognitive ability
cognitive function
polyunsaturated fatty acids (PUFAs)
Rodents
soy lecithin
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Summary:In experiments conducted on white rats neurotropic action of soy lecithin, known as a source of unsaturated fatty acids on the background of the neurotoxic impact of CCl4was studied. Useage of CCl4by courses showed a significant inhibitory effect that affected the spontaneous behavior of rats “in the open field” by significant inhibition of mobility (44 - 77%), research activity (81%) and increased emotionality (140%). Suchusageofsoy lecithin having anti-oxidant activity and membrane-stabilizing effect led to optimization of spontaneous behavior of rats. Theinfringement of cognitive function is, possibly, due to the prooxydative effect ofCCl4 anddecreaseintheunsaturated fatty acid fraction in the structure of the brain lipids.Level of research, mink instinct, emotionality, vertical mobility were restored, and horizontal mobility even increased by 59%. Thus, soy lecithin may be recommended as a drug with correcting cognitive brain function.
ISSN:2307-0404
2307-0404
DOI:10.26641/2307-0404.2015.1.40230