Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

• Published in: Brain and behavior 2021-12, Vol.11 (12), p.e2434-n/a
• Main Authors: Cheng, Fan, Si, Xiao‐Min, Yang, Gong‐Li, Zhou, Lan
• Format: Article
• Language: English
• Subjects: Adipocytes; Age; Atherosclerosis; Diabetes; Ethnicity; Gene expression; Genetic Predisposition to Disease - genetics; Genotype & phenotype; Humans; Ischemic Stroke; Lipids; Meta-analysis; Metabolism; Mutation; Odds Ratio; Older people; Original; Polymorphism; Polymorphism, Single Nucleotide; PPAR gamma - genetics; PPAR‐γ; Stroke; Systematic review; Thrombosis; White people
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.2434

Background Published researches have suggested some associations between PPAR‐γ and ischemic stroke (IS) development. This meta‐analysis was conducted to evaluate the association between PPAR‐γ gene polymorphisms and IS risk. Materials and methods A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR‐γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted. Result Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09–4.35, p = .03, I2 = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07–4.32, p = .03, I2 = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk. Conclusion In conclusion, our study showed that PPAR‐γ rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future. Ischemic strokes (IS) are one of the most common diseases resulting in disabilities and death among adults. Our meta‐analysis indicated that the individuals with G mutation of rs1801282 C/G polymorphism would face an increased risk of IS. But there was no significant association between rs3856806 C/T polymorphism and IS risk.