Association between endothelial nitric oxide synthase (eNOS) gene variants and nitric oxide production in preeclampsia: a case–control study in Ghana

Evidence suggests that a major cause of PE is endothelial dysfunction emanating from the reduced bioavailability of Nitric oxide (NO). Variants of endothelial nitric oxide synthase (eNOS) gene may lead to decreased NO levels. We explored the association between eNOS gene variants and nitric oxide le...

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Bibliographic Details
Published in:Scientific reports 2023-09, Vol.13 (1), p.14740-14740, Article 14740
Main Authors: Fondjo, Linda Ahenkorah, Awuah, Enoch Ofori, Sakyi, Samuel Asamoah, Senu, Ebenezer, Detoh, Eric
Format: Article
Language:English
Subjects:
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Alleles
Bioavailability
Case studies
Genotypes
Humanities and Social Sciences
multidisciplinary
Nitric oxide
Nitric-oxide synthase
Population studies
Pre-eclampsia
Preeclampsia
Risk reduction
Science
Science (multidisciplinary)
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Summary:Evidence suggests that a major cause of PE is endothelial dysfunction emanating from the reduced bioavailability of Nitric oxide (NO). Variants of endothelial nitric oxide synthase (eNOS) gene may lead to decreased NO levels. We explored the association between eNOS gene variants and nitric oxide levels among preeclamptic women in the Ghanaian population. This case–control study included 75 preeclamptic women and 75 healthy normotensive pregnant women attending antenatal care at the Nkawie-Toase Government Hospital, Ghana. A well-structured questionnaire was used to collect socio-demographic, obstetric and clinical data. Blood was obtained for DNA extraction; the gene variants were determined using PCR and RFLP. Preeclamptic women had significantly lower NO concentration compared to the normotensives ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-41920-w