Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus

The role of adipocyte hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance in studies of type 2 diabetes mellitus. Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin...

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Bibliographic Details
Published in:Annals of Saudi medicine 2005-07, Vol.25 (4), p.283-287
Main Authors: Al-Harithy, Rowyda N, Al-Ghamdi, Shareefa
Format: Article
Language:English
Subjects:
Adiposity - physiology
Aged
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Female
Humans
Insulin Resistance - physiology
Middle Aged
Obesity - blood
Obesity - physiopathology
Original
Resistin - blood
Saudi Arabia - epidemiology
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Summary:The role of adipocyte hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance in studies of type 2 diabetes mellitus. Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin resistance, but its relevance to human diabetes remains uncertain. Therefore, we assessed the relationship between serum resistin concentrations and insulin resistance in lean, overweight and obese (OW/OB) non-diabetic and diabetic Saudi women. We measured fasting serum resistin levels in 44 diabetic women with a mean body mass index (BMI) of 31.82 +/- 4.35 kg/m2, 21 OW/OB non-diabetic women with a mean BMI 30.71 +/- 3.42 kg/m2 and in 24 lean women with a mean BMI of 23.33 +/- 1.24 kg/m2. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. The concentrations of fasting serum resistin showed significant differences among the three groups (P
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2005.283