Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cell-Based Models

Inherited heart diseases (IHDs) are caused by genetic mutations that disrupt the physiological structure and function of the heart. Understanding the mechanisms behind these diseases is crucial for developing personalised interventions in cardiovascular medicine. Development of induced pluripotent s...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2024-11, Vol.14 (11), p.1370
Main Author: Wang, Brian Xiangzhi
Format: Article
Language:English
Subjects:
arrhythmia
Cardiac arrhythmia
Cardiac function
Cardiomyocytes
Cardiomyopathy
Cardiovascular agents
Cardiovascular diseases
Cell culture
Cell differentiation
Clinical medicine
Costs
Customization
Disease
disease modelling
Fibroblasts
Gene mutations
Gene therapy
Genetic aspects
Genetic testing
Global health
Heart
Heart diseases
inherited heart disease
Investigations
Medical innovations
Medical research
Medicine, Experimental
Molecular modelling
Mutation
Organoids
Pathophysiology
Pediatrics
Pluripotency
Proteins
Review
stem cell
Stem cells
Structure-function relationships
Tissue culture
Tissue engineering
Transcription factors
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Summary:Inherited heart diseases (IHDs) are caused by genetic mutations that disrupt the physiological structure and function of the heart. Understanding the mechanisms behind these diseases is crucial for developing personalised interventions in cardiovascular medicine. Development of induced pluripotent stem cells, which can then be differentiated to any nucleated adult cell type, has enabled the creation of personalised single-cell and multicellular models, providing unprecedented insights into the pathophysiology of IHDs. This review provides a comprehensive overview of recent advancements in human iPSC models used to dissect the molecular and genetic underpinnings of common IHDs. We examine multicellular models and tissue engineering approaches, such as cardiac organoids, engineered heart tissue, and multicellular co-culture systems, which simulate complex intercellular interactions within heart tissue. Recent advancements in stem cell models offer a more physiologically relevant platform to study disease mechanisms, enabling researchers to observe cellular interactions, study disease progression, and identify therapeutic strategies. By leveraging these innovative models, we can gain deeper insights into the molecular and cellular mechanisms underlying IHDs, ultimately paving the way for more effective diagnostic and therapeutic strategies.
ISSN:2075-1729
2075-1729
DOI:10.3390/life14111370